2. Gene
  3. Ghrl - ghrelin and obestatin prepropeptide Gene

Ghrl - ghrelin and obestatin prepropeptide Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 59301 | 基因类型: protein coding

关于 Ghrl

功能概要

Enables ghrelin receptor binding activity and growth hormone-releasing hormone activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of peptide hormone secretion; and regulation of digestive system process. Acts upstream of or within negative regulation of Insulin secretion. Located in cytoplasm. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study middle cerebral artery infarction. Biomarker of multiple endocrine neoplasia and obstructive sleep apnea. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

Ghrl 基因产物(1)

mRNA Protein Name
NM_021669.2 NP_067701.1 appetite-regulating hormone preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor binding IPI
IPI: 通过物理相互作用推断
10604470 RGD
enables ghrelin receptor binding IMP
IMP: 通过突变表型推断
17109695 RGD
enables growth hormone-releasing hormone activity IDA
IDA: 通过直接分析推断
10604470 RGD
enables hormone activity IDA
IDA: 通过直接分析推断
17109695 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
10604470 RGD
involved in gastric acid secretion IDA
IDA: 通过直接分析推断
17705669 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
17543279 RGD
acts upstream of or within negative regulation of insulin secretion IDA
IDA: 通过直接分析推断
17130496 RGD
involved in negative regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
19620309 RGD
involved in negative regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
19620309 RGD
involved in positive regulation of adipose tissue development IDA
IDA: 通过直接分析推断
14551228 RGD
involved in positive regulation of appetite IMP
IMP: 通过突变表型推断
15994217 RGD
involved in positive regulation of bone development IDA
IDA: 通过直接分析推断
12960077 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
11756331 RGD
involved in positive regulation of eating behavior IDA
IDA: 通过直接分析推断
14551228 RGD
involved in positive regulation of feeding behavior IDA
IDA: 通过直接分析推断
17033095 RGD
involved in positive regulation of gastric mucosal blood circulation IDA
IDA: 通过直接分析推断
17033095 RGD
involved in positive regulation of gastro-intestinal system smooth muscle contraction IDA
IDA: 通过直接分析推断
15890336 RGD
involved in positive regulation of growth IDA
IDA: 通过直接分析推断
12960077 RGD
involved in positive regulation of growth hormone secretion IDA
IDA: 通过直接分析推断
10604470 RGD
involved in positive regulation of growth rate IDA
IDA: 通过直接分析推断
17033095 RGD
involved in positive regulation of insulin secretion IDA
IDA: 通过直接分析推断
11756331 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
16647196 RGD
involved in positive regulation of response to food IDA
IDA: 通过直接分析推断
17065340 RGD
involved in positive regulation of small intestinal transit IDA
IDA: 通过直接分析推断
21874246 RGD
involved in positive regulation of small intestine smooth muscle contraction IDA
IDA: 通过直接分析推断
15890336 RGD
involved in positive regulation of sprouting angiogenesis IDA
IDA: 通过直接分析推断
21642627 RGD
involved in positive regulation of vascular endothelial cell proliferation IDA
IDA: 通过直接分析推断
21642627 RGD
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
26153524 RGD
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
26153524 RGD
involved in regulation of gastric motility IDA
IDA: 通过直接分析推断
23525979 RGD
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
22516464 RGD
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
22516464 RGD
involved in regulation of response to food IDA
IDA: 通过直接分析推断
17065340 RGD
involved in regulation of transmission of nerve impulse IDA
IDA: 通过直接分析推断
23525979 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
23525979 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
26512025 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
26153524 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
26153524 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22516464 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
22516464 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

appetite-regulating hormone

ghrelin/obestatin prepropeptide

growth hormone secretagogue

growth hormone-releasing peptide

motilin-related peptide

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05415 GHRL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20741 Ghrl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27253 Ghrl Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ghrl NCBI NCBI:51738
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