1. Gene
  2. CHTF18 - chromosome transmission fidelity factor 18 Gene

CHTF18 - chromosome transmission fidelity factor 18 Gene

中文名称:染色体传递保真因子 18

种属: Homo sapiens

同用名: CHL12; Ctf18; RUVBL; C16orf41; C321D2.2; C321D2.3; C321D2.4

基因 ID: 63922 | 基因类型: protein coding

关于 CHTF18

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:788,620-798,074 (from NCBI)

This gene has 20 transcripts (splice variants) and 160 orthologues. Broad expression in bone marrow (RPKM 7.1), testis (RPKM 6.3) and 24 other tissues.

功能概要

该基因编码的蛋白质是复制因子 C (RFC) 复合物的一个组成部分,它在细胞周期的 S 期将增殖细胞核抗原 (PCNA) 加载到 DNA 上。编码的蛋白质可能与其他蛋白质 (包括 RFC 复合物 3) 相互作用,形成一个钳夹加载器复合物,在中期 - 后期转变期间在姐妹染色单体凝聚中发挥作用。[RefSeq 提供,2016 年 1 月]

This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with Other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016]

CHTF18 基因产物(1)

mRNA Protein Name
NM_022092.3 NP_071375.1 chromosome transmission fidelity protein 18 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to DNA clamp loader activity IDA
IDA: 通过直接分析推断
12930902 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12930902 GOA
contributes to single-stranded DNA helicase activity IDA
IDA: 通过直接分析推断
12930902 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-directed DNA polymerase activity IDA
IDA: 通过直接分析推断
12930902 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Ctf18 RFC-like complex IDA
IDA: 通过直接分析推断
12930902 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CHTF18 蛋白结构

AAA

AAA: ATPase family associated with various cellular activities (AAA) (371 - 440)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 975 a.a.
蛋白主名 其他名称

chromosome transmission fidelity protein 18 homolog

CTF18, chromosome transmission fidelity factor 18 homolog

关联疾病

疾病名称 别名
Roberts-Sc Phocomelia Syndrome

Roberts Syndrome

Sc Phocomelia Syndrome

RBS

Long Bone Deficiencies Associated With Cleft Lip-Palate

Sc Pseudothalidomide Syndrome

Appelt-Gerken-Lenz Syndrome

Pseudothalidomide Syndrome

Tetraphocomelia-Cleft Palate Syndrome

Hypomelia Hypotrichosis Facial Hemangioma Syndrome

Roberts Syndrome/Sc Phocomelia

Roberts Tetraphocomelia Syndrome

Sc Syndrome

Sc Phocomelia

Sc Disease

Sc

Hemoglobin Sc Disease

Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CHTF18 VGNC VGNC:82344
Mus musculus CHTF18 MGD MGI:2384887
Macaca mulatta CHTF18 VGNC VGNC:71004
Rattus norvegicus CHTF18 RGD RGD:1310473
Canis familiaris CHTF18 VGNC VGNC:39260
Bos taurus CHTF18 VGNC VGNC:27352