1. Gene
  2. TNN - tenascin N Gene

TNN - tenascin N Gene

中文名称:肌腱蛋白 N

种属: Homo sapiens

同用名: TNW; TN-W

基因 ID: 63923 | 基因类型: protein coding

关于 TNN

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:175,067,833-175,148,075 (from NCBI)

This gene has 2 transcripts (splice variants), 126 orthologues and 25 paralogues. Biased expression in fat (RPKM 11.1), thyroid (RPKM 1.5) and 2 other tissues.

功能概要

预测启用整合素结合活动。预计参与多个过程,包括神经元的生成;参与成骨细胞分化的经典 Wnt 信号通路的负调控;成骨细胞分化的负调控。预计在轴突发生的上游或轴突发生内起作用。预测位于细胞外基质和神经元投射。预计在含胶原蛋白的细胞外基质和细胞外间隙中具有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable Integrin binding activity. Predicted to be involved in several processes, including generation of neurons; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; and negative regulation of osteoblast differentiation. Predicted to act upstream of or within axonogenesis. Predicted to be located in extracellular matrix and neuron projection. Predicted to be active in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TNN 基因产物(1)

mRNA Protein Name
NM_022093.2 NP_071376.1 tenascin-N precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of sprouting angiogenesis IDA
IDA: 通过直接分析推断
19884327 GOA
involved in regulation of cell adhesion IDA
IDA: 通过直接分析推断
17909022 GOA
involved in regulation of cell migration IDA
IDA: 通过直接分析推断
17909022 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
19884327 GOA
part of tenascin complex IPI
IPI: 通过物理相互作用推断
17909022 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TNN 蛋白结构

fn3

fn3: Fibronectin type III domain (265 - 337)

fn3

fn3: Fibronectin type III domain (359 - 430)

fn3

fn3: Fibronectin type III domain (445 - 518)

fn3

fn3: Fibronectin type III domain (533 - 608)

fn3

fn3: Fibronectin type III domain (622 - 697)

fn3

fn3: Fibronectin type III domain (710 - 786)

fn3

fn3: Fibronectin type III domain (799 - 874)

fn3

fn3: Fibronectin type III domain (888 - 962)

fn3

fn3: Fibronectin type III domain (974 - 1047)

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (1067 - 1276)

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  • 1299 a.a.
蛋白主名 其他名称

tenascin-N

TN-N

关联疾病

疾病名称 别名
Spondyloepiphyseal Dysplasia, Nishimura Type

SEDN

Spondyloepiphyseal Dysplasia Nishimura Type

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TNN RGD RGD:1306002
Felis catus TNN VGNC VGNC:66424
Mus musculus TNN MGD MGI:2665790
Canis familiaris TNN VGNC VGNC:47685
Bos taurus TNN VGNC VGNC:36188
Macaca mulatta TNN VGNC VGNC:79359
Others TNN NCBI