2. Gene
  3. PCIF1 - phosphorylated CTD interacting factor 1 Gene

PCIF1 - phosphorylated CTD interacting factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸化 CTD 相互作用因子 1

种属: Homo sapiens

同用名: CAPAM; hCAPAM; hPCIF1; C20orf67; PPP1R121

基因 ID: 63935 | 基因类型: protein coding

关于 PCIF1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,934,683-45,948,020 (from NCBI)

This gene has 3 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in ovary (RPKM 21.7), thyroid (RPKM 17.5) and 25 other tissues.

功能概要

启用 RNA 聚合酶 II C 端域磷酸丝氨酸结合活性； S-腺苷-L-甲硫氨酸结合活性；和 mRNA (2'-O-甲基腺苷-N6-) -甲基转移酶活性。参与 mRNA 甲基化；翻译的负调节；和翻译的积极调节。位于细胞间桥；微管细胞骨架；和核质。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II C-terminal domain phosphoserine binding activity; S-adenosyl-L-methionine binding activity; and mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA methylation; negative regulation of translation; and positive regulation of translation. Located in intercellular bridge; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PCIF1 基因产物(1)

mRNA Protein Name
NM_022104.4 NP_071387.1 mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II C-terminal domain binding IDA
IDA: 通过直接分析推断
18294453 GOA
enables RNA polymerase II C-terminal domain phosphoserine binding IDA
IDA: 通过直接分析推断
32814042 GOA
enables S-adenosyl-L-methionine binding IDA
IDA: 通过直接分析推断
30467178 GOA
enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IDA
IDA: 通过直接分析推断
30467178 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA processing IDA
IDA: 通过直接分析推断
30467178 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
31279659 GOA
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
30467178 GOA
NOT involved in regulation of translation IDA
IDA: 通过直接分析推断
31279658 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18294453 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCIF1 蛋白结构

WW

WW: WW domain (48 - 75)

PCIF1_WW

PCIF1_WW: Phosphorylated CTD interacting factor 1 WW domain (446 - 621)

  • 0
  • 200
  • 400
  • 600
  • 704 a.a.
蛋白主名 其他名称

mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase

PDX-1 C terminus-interacting factor 1

关联疾病

疾病名称 别名
Childhood Supratentorial Ependymoma

Paediatric Cerebral Ependymoma

Paediatric Supratentorial Ependymoblastoma

Paediatric Supratentorial Ependymoma

Pediatric Cerebral Ependymoma

Pediatric Supratentorial Ependymoblastoma

Pediatric Supratentorial Ependymoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10151 PCIF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16789 Spop Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PCIF1 RGD RGD:1310800
Mus musculus PCIF1 MGD MGI:2443858
Bos taurus PCIF1 VGNC VGNC:32630
Canis familiaris PCIF1 VGNC VGNC:44306
Macaca mulatta PCIF1 VGNC VGNC:75621
Felis catus PCIF1 VGNC VGNC:81142
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