2. Gene
  3. Isl1 - ISL LIM homeobox 1 Gene

Isl1 - ISL LIM homeobox 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Isl-1; isl-1=homeobox

基因 ID: 64444 | 基因类型: protein coding

关于 Isl1

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Estrogen receptor binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; negative regulation of intracellular Estrogen receptor signaling pathway; and positive regulation of Insulin secretion. Located in nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Isl1 基因产物(1)

mRNA Protein Name
NM_017339.3 NP_059035.3 insulin gene enhancer protein ISL-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
19619559 RGD
enables LIM domain binding IMP
IMP: 通过突变表型推断
26260513 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
19619559 RGD
enables core promoter sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11043578 RGD
enables nuclear estrogen receptor binding IDA
IDA: 通过直接分析推断
11043578 RGD
enables nuclear receptor binding IDA
IDA: 通过直接分析推断
11043578 RGD
enables nuclear receptor binding IPI
IPI: 通过物理相互作用推断
11043578 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9315627 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
1691825 RGD
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
18539116 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon regeneration IEP
IEP: 通过表达模式推断
10363827 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: 通过表达模式推断
19619559 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
23270756 RGD
involved in negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
23270756 RGD
involved in negative regulation of intracellular estrogen receptor signaling pathway IDA
IDA: 通过直接分析推断
11043578 RGD
involved in negative regulation of mesenchymal cell proliferation IMP
IMP: 通过突变表型推断
23270756 RGD
involved in negative regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
11043578 RGD
involved in positive regulation of calcium ion import IMP
IMP: 通过突变表型推断
29678908 RGD
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
23270756 RGD
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
11978636 RGD
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
29678908 RGD
involved in positive regulation of smoothened signaling pathway IDA
IDA: 通过直接分析推断
32544883 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16613990 RGD
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
18539116 RGD
involved in positive regulation of type B pancreatic cell apoptotic process IMP
IMP: 通过突变表型推断
30341898 RGD
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
7759514 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
30341898 RGD
located in nucleus IDA
IDA: 通过直接分析推断
11043578 RGD
part of transcription regulator complex IDA
IDA: 通过直接分析推断
18539116 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

insulin gene enhancer protein ISL-1

ISL1 transcription factor LIM/homeodomain (islet-1)

ISL1 transcription factor, LIM/homeodomain 1

isl-1 homeobox

islet-1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06931 ISL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174594 Human ISL1 mRNA / 否
HY-RS18481 Isl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24962 Isl1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Isl1 NCBI NCBI:3670
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