2. Gene
  3. ILRUN - inflammation and lipid regulator with UBA-like and NBR1-like domains Gene

ILRUN - inflammation and lipid regulator with UBA-like and NBR1-like domains Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：具有 UBA 样和 NBR1 样结构域的炎症和脂质调节因子

种属: Homo sapiens

同用名: FP852; C6orf106; dJ391O22.4

基因 ID: 64771 | 基因类型: protein coding

关于 ILRUN

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,587,288-34,696,767 (from NCBI)

This gene has 3 transcripts (splice variants) and 262 orthologues. Ubiquitous expression in fat (RPKM 19.9), testis (RPKM 15.9) and 25 other tissues.

功能概要

该基因编码的蛋白质具有 N 末端泛素相关 (UBA) 样和 BRCA1 基因 1 (NBR1) 样结构域的中心邻居。该蛋白是抗病毒和促炎细胞因子转录的抑制剂，也是肾素-血管紧张素-醛固酮系统 (RAAS) 的调节剂。[RefSeq 提供，2021 年 7 月]

This gene encodes a protein with N-terminal ubiquitin-associated (UBA)-like and central neighbor of BRCA1 gene 1 (NBR1)-like domains. The protein acts an inhibitor of Antiviral and proinflammatory cytokine transcription and as a regulator of the renin-angiotensin-aldosterone system (RAAS). [provided by RefSeq, Jul 2021]

ILRUN 基因产物(2)

mRNA Protein Name
NM_022758.6 NP_073595.2 protein ILRUN isoform b
NM_024294.4 NP_077270.1 protein ILRUN isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
29802199 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA binding IDA
IDA: 通过直接分析推断
29802199 GOA
involved in negative regulation of defense response to virus IMP
IMP: 通过突变表型推断
29802199 GOA
involved in negative regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
29802199 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
29802199 GOA
involved in negative regulation of type I interferon production IMP
IMP: 通过突变表型推断
29802199 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
29802199 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29802199 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ILRUN 蛋白结构

UBA_4

UBA_4: UBA-like domain (26 - 66)

  • 0
  • 100
  • 200
  • 298 a.a.
蛋白主名 其他名称

protein ILRUN

inflammation and lipid regulator with UBA-like and NBR1-like domains protein

关联疾病

疾病名称 别名
Meninges Sarcoma

Meningeal Sarcoma

Sarcoma Of Meninges

Meningothelial Sarcoma

Leptomeningeal Sarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06789 ILRUN Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ILRUN RGD RGD:1559829
Mus musculus ILRUN MGD MGI:106281
Macaca mulatta ILRUN VGNC VGNC:83428
Bos taurus ILRUN VGNC VGNC:52675
Canis familiaris ILRUN VGNC VGNC:49210
Felis catus ILRUN VGNC VGNC:102443
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