2. Gene
  3. SLIT3 - slit guidance ligand 3 Gene

SLIT3 - slit guidance ligand 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：狭缝引导配体 3

种属: Homo sapiens

同用名: MEGF5; SLIL2; SLIT1; slit2; Slit-3

基因 ID: 6586 | 基因类型: protein coding

关于 SLIT3

Cytogenetic location: 5q34-q35.1 Genomic coordinates (GRCh38): 5:168,661,740-169,301,139 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 25 paralogues. Broad expression in fat (RPKM 23.0), gall bladder (RPKM 21.4) and 22 other tissues.

功能概要

由该基因编码的蛋白质被分泌出来，可能与迂回同系物受体相互作用以影响细胞迁移。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2012 年 12 月]

The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

SLIT3 基因产物(2)

mRNA Protein Name
NM_001271946.2 NP_001258875.2 slit homolog 3 protein isoform 1 precursor
NM_003062.4 NP_003053.2 slit homolog 3 protein isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Roundabout binding IPI
IPI: 通过物理相互作用推断
15207848 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Roundabout signaling pathway IMP
IMP: 通过突变表型推断
18829537 GOA
involved in apoptotic process involved in luteolysis IEP
IEP: 通过表达模式推断
18566128 GOA
involved in axon extension involved in axon guidance IDA
IDA: 通过直接分析推断
16840550 GOA
involved in axon guidance IDA
IDA: 通过直接分析推断
11748139 GOA
involved in cellular response to hormone stimulus IEP
IEP: 通过表达模式推断
18566128 GOA
NOT involved in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA
IDA: 通过直接分析推断
11748139 GOA
involved in negative chemotaxis IDA
IDA: 通过直接分析推断
11748139 GOA
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
18829537 GOA
involved in negative regulation of chemokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
18829537 GOA
involved in response to cortisol IEP
IEP: 通过表达模式推断
18566128 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
19741192 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLIT3 蛋白结构

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (33 - 60)

LRR_8

LRR_8: Leucine rich repeat (110 - 169)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (240 - 264)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (280 - 306)

LRR_8

LRR_8: Leucine rich repeat (332 - 391)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (462 - 486)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (505 - 531)

LRR_8

LRR_8: Leucine rich repeat (534 - 593)

LRR_8

LRR_8: Leucine rich repeat (606 - 664)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (687 - 712)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (725 - 751)

LRR_8

LRR_8: Leucine rich repeat (799 - 859)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (882 - 906)

EGF

EGF: EGF-like domain (959 - 992)

EGF

EGF: EGF-like domain (1000 - 1029)

EGF

EGF: EGF-like domain (1038 - 1069)

EGF

EGF: EGF-like domain (1078 - 1107)

EGF

EGF: EGF-like domain (1124 - 1153)

Laminin_G_2

Laminin_G_2: Laminin G domain (1187 - 1314)

hEGF

hEGF: Human growth factor-like EGF (1352 - 1364)

EGF

EGF: EGF-like domain (1372 - 1400)

hEGF

hEGF: Human growth factor-like EGF (1432 - 1443)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1523 a.a.
蛋白主名 其他名称

slit homolog 3 protein

multiple EGF-like domains protein 5

关联疾病

疾病名称 别名
Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic

Familial Hepatic Adenoma

Familial Liver Cell Adenomas

Liver Cell Adenomas, Familial

Hepatic Adenomas Familial

HEPAF

Ha

Hepatocellular Adenomas

Hepatocellular Adenoma
Diaphragm Disease

Abnormality Of The Diaphragm

Disease Of Diaphragm

Diaphragmatic Disorder

Disorder Of Diaphragm
Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect
Vesicoureteral Reflux

Vesico-Ureteral Reflux
Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1
Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13370 SLIT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13372 SLIT3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20490 Slit3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26998 Slit3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SLIT3 VGNC VGNC:34961
Canis familiaris SLIT3 VGNC VGNC:46505
Rattus norvegicus SLIT3 RGD RGD:69311
Mus musculus SLIT3 MGD MGI:1315202
Macaca mulatta SLIT3 VGNC VGNC:77645
Felis catus SLIT3 VGNC VGNC:65453
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