2. Gene
  3. Smarca2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Gene

Smarca2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: brm; Snf2l2; brahma; SNF2alpha; 2610209L14Rik

基因 ID: 67155 | 基因类型: protein coding

关于 Smarca2

功能概要

Predicted to enable several functions, including chromatin binding activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Acts upstream of or within aortic smooth muscle cell differentiation; hematopoietic stem cell homeostasis; and negative regulation of cell population proliferation. Located in nucleus. Part of nBAF complex and npBAF complex. Is expressed in several structures, including cerebral cortex; early conceptus; genitourinary system; heart; and vitelline artery. Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2). [provided by Alliance of Genome Resources, Apr 2022]

Smarca2 基因产物(10)

mRNA Protein Name
NM_001347439.2 NP_001334368.1 probable global transcription activator SNF2L2 isoform 3 precursor
NM_001405130.1 NP_001392059.1 probable global transcription activator SNF2L2 isoform 1
NM_001405131.1 NP_001392060.1 probable global transcription activator SNF2L2 isoform 1
NM_001405132.1 NP_001392061.1 probable global transcription activator SNF2L2 isoform 1
NM_001405133.1 NP_001392062.1 probable global transcription activator SNF2L2 isoform 4
NM_001405134.1 NP_001392063.1 probable global transcription activator SNF2L2 isoform 4
NM_001405135.1 NP_001392064.1 probable global transcription activator SNF2L2 isoform 4
NM_001405136.1 NP_001392065.1 probable global transcription activator SNF2L2 isoform 4
NM_011416.3 NP_035546.2 probable global transcription activator SNF2L2 isoform 1
NM_026003.3 NP_080279.1 probable global transcription activator SNF2L2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12368262 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within aortic smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
19342595 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
9843504 MGI
acts upstream of fibroblast proliferation IMP
IMP: 通过突变表型推断
9843504 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: 通过突变表型推断
26880577 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
9843504 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
9843504 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SWI/SNF superfamily-type complex IDA
IDA: 通过直接分析推断
12368262 MGI
part of nBAF complex IDA
IDA: 通过直接分析推断
17640523 MGI
part of npBAF complex IDA
IDA: 通过直接分析推断
17640523 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9603422 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

probable global transcription activator SNF2L2

ATP-dependent helicase SMARCA2

BAF190B

BRG1-associated factor 190B

SNF2-alpha

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

protein brahma homolog

subunit of the SWI/SNF chromatin remodeling complex

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-159607 PRT3789 Degrader / Phase 2
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128359 ACBI1 Degrader 99.92% 否
HY-44012 SMARCA-BD ligand 1 for PROTAC Ligand 99.07% 否
HY-44012B SMARCA-BD ligand 1 for PROTAC hydrochloride Ligand 99.24% 否
HY-44012A SMARCA-BD ligand 1 for PROTAC dihydrochloride Ligand 98.08% 否
HY-44824 SMARCA2 ligand-13 Ligand / 否
HY-180931 PROTAC A515 Degrader / 否
HY-180932 SMARCA2 ligand-17 Ligand / 否
HY-180960 NEP202 Degrader / 否
HY-176871 PROTAC SMARCA2 degrader-35 Degrader / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smarca2 NCBI NCBI:6595
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