2. Gene
  3. TCF7L2 - Tcf7l2 transcription factor 7 like 2 Gene

TCF7L2 - Tcf7l2 transcription factor 7 like 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 679869 | 基因类型: protein coding

关于 TCF7L2

功能概要

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; armadillo repeat domain binding activity; and beta-catenin binding activity. Involved in negative regulation of apoptotic process and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of beta-catenin-TCF7L2 complex and protein-DNA complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate Cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Apr 2022]

TCF7L2 基因产物(1)

mRNA Protein Name
NM_001191052.2 NP_001177981.1 transcription factor 7-like 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
21901280 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21965303 RGD
involved in negative regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
21901280 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21901280 RGD
involved in negative regulation of type B pancreatic cell apoptotic process IMP
IMP: 通过突变表型推断
21965303 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21965303 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcription factor 7-like 2

transcription factor 7-like 2 (T-cell specific, HMG-box)

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W010995 2,5-Dimethylcelecoxib Inhibitor 99.57% 否
HY-N3628 Coronarin A Inhibitor ≥98.0% 否
HY-RS14310 TCF7L2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17858 Tcf7l2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24327 Tcf7l2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens TCF7L2 NCBI NCBI:6934
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