2. Gene
  3. Nipbl - NIPBL cohesin loading factor Gene

Nipbl - NIPBL cohesin loading factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Idn3

基因 ID: 71175 | 基因类型: protein coding

关于 Nipbl

功能概要

Enables mediator complex binding activity and promoter-specific chromatin binding activity. Involved in cohesin loading; positive regulation of neuron migration; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; fat cell differentiation; and positive regulation of ossification. Located in chromatin and nucleus. Part of integrator complex. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and nose. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Orthologous to human NIPBL (NIPBL cohesin loading factor). [provided by Alliance of Genome Resources, Apr 2022]

Nipbl 基因产物(2)

mRNA Protein Name
NM_027707.3 NP_081983.2 nipped-B-like protein isoform a
NM_201232.2 NP_957684.1 nipped-B-like protein isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
20720539 MGI
enables cohesin loader activity IMP
IMP: 通过突变表型推断
29094699 MGI
enables mediator complex binding IDA
IDA: 通过直接分析推断
20720539 MGI
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
28041881 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
28041881 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: 通过突变表型推断
19763162 MGI
acts upstream of or within embryonic viscerocranium morphogenesis IMP
IMP: 通过突变表型推断
19763162 MGI
acts upstream of or within fat cell differentiation IMP
IMP: 通过突变表型推断
19763162 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
19763162 MGI
involved in mitotic sister chromatid segregation IMP
IMP: 通过突变表型推断
29094699 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
19763162 MGI
involved in positive regulation of neuron migration IMP
IMP: 通过突变表型推断
28041881 MGI
acts upstream of or within positive regulation of ossification IMP
IMP: 通过突变表型推断
19763162 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23920377 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
28041881 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: 通过突变表型推断
20720539 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
23920377 MGI
part of integrator complex IDA
IDA: 通过直接分析推断
28041881 MGI
located in nucleus IDA
IDA: 通过直接分析推断
29094699 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nipped-B-like protein

Nipped-B homolog

SCC2 homolog

delangin homolog

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09305 NIPBL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21000 Nipbl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27517 Nipbl Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nipbl NCBI NCBI:25836
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