Ehmt1 - euchromatic histone methyltransferase 1 Gene

中文名称：常染色质组蛋白甲基转移酶 1

种属: Mus musculus

同用名: GLP; GLP1; KMT1D; mKIAA1876; D330003E03; Eu-HMTase1; 9230102N17Rik

关于 Ehmt1

功能概要

该基因编码的蛋白可启动 C2H2 锌指结构域结合活性；组蛋白甲基转移酶活性（H3-K27 特异性）；和组蛋白甲基转移酶活性（H3-K9 特异性）。参与多个过程，包括大分子甲基化；转录的负调控，DNA 模板化；和冷诱导产热的正调节。在 RNA 聚合酶 II 的转录负调节上游或负调节内起作用。位于核内。以多种结构表达，包括消化系统；前肢;外皮系统；神经系统;和呼吸系统。用于研究 Kleefstra 综合征 1。与 Kleefstra 综合征和 Kleefstra 综合征 1 有关的该基因的人类直向同源基因。与人类 EHMT1（常染色质组蛋白赖氨酸甲基转移酶 1）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables C2H2 zinc finger domain binding activity; Histone Methyltransferase activity (H3-K27 specific); and Histone Methyltransferase activity (H3-K9 specific). Involved in several processes, including macromolecule methylation; negative regulation of transcription, DNA-templated; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; forelimb; integumental system; nervous system; and respiratory system. Used to study Kleefstra syndrome 1. Human ortholog(s) of this gene implicated in Kleefstra syndrome and Kleefstra syndrome 1. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]