2. Gene
  3. IRX3 - iroquois homeobox 3 Gene

IRX3 - iroquois homeobox 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：易洛魁人同源框 3

种属: Homo sapiens

同用名: IRX-1; IRXB1

基因 ID: 79191 | 基因类型: protein coding

关于 IRX3

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:54,283,304-54,286,787 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 6 paralogues. Biased expression in lung (RPKM 13.1), skin (RPKM 8.6) and 10 other tissues.

功能概要

IRX3 是易洛魁族同源框基因家族的成员 (参见 IRX1；MIM 606197) ，并在神经发育的早期阶段发挥作用 (Bellefroid 等人，1998 [PubMed 9427753]) 。这个家族的成员似乎在脊椎动物胚胎的模式形成过程中扮演着多重角色 (Lewis 等人，1999 [PubMed 10370142]) 。[OMIM 提供，2009 年 8 月]

IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]

IRX3 基因产物(1)

mRNA Protein Name
NM_024336.3 NP_077312.2 iroquois-class homeodomain protein IRX-3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRX3 蛋白结构

Homeobox_KN

Homeobox_KN: Homeobox KN domain (145 - 184)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
蛋白主名 其他名称

iroquois-class homeodomain protein IRX-3

homeodomain protein IRXB1

关联疾病

疾病名称 别名
Aniseikonia
Transient Refractive Change
Cycloplegia

Ciliary Muscle Paresis

Cycloplegic Paralysis Of Accommodation

Paresis Of Accommodation

Visual Accommodation Paralysis

Accommodation Paralysis

Intrinsic Paralysis Of Eye Muscle

Cycloplegic
Eye Accommodation Disease
Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06922 IRX3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06925 IRX6 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20756 Irx3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27269 Irx3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IRX3 RGD RGD:1307424
Mus musculus IRX3 MGD MGI:1197522
Canis familiaris IRX3 VGNC VGNC:42102
Macaca mulatta IRX3 VGNC VGNC:99517
Bos taurus IRX3 VGNC VGNC:30287
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