2. Gene
  3. IRX1 - iroquois homeobox 1 Gene

IRX1 - iroquois homeobox 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：易洛魁人同源框 1

种属: Homo sapiens

同用名: IRX-5; IRXA1

基因 ID: 79192 | 基因类型: protein coding

关于 IRX1

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:3,595,832-3,601,403 (from NCBI)

This gene has 1 transcript (splice variant), 186 orthologues and 6 paralogues. Biased expression in kidney (RPKM 2.5), salivary gland (RPKM 1.1) and 4 other tissues.

功能概要

该基因编码易洛魁人同源框蛋白家族的一个成员。该家族中的同源框基因参与胚胎中的模式形成。该基因产物已被鉴定为胃癌 (PMID：21602894、20440264) 和头颈癌 (PMID：18559491) 的肿瘤抑制因子。该基因的假基因位于 13 号染色体上。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]

IRX1 基因产物(1)

mRNA Protein Name
NM_024337.4 NP_077313.3 iroquois-class homeodomain protein IRX-1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
20440264 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20440264 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRX1 蛋白结构

Homeobox_KN

Homeobox_KN: Homeobox KN domain (145 - 184)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
蛋白主名 其他名称

iroquois-class homeodomain protein IRX-1

homeodomain protein IRXA1

关联疾病

疾病名称 别名
Pulmonary Immaturity

Primary Atelectasis Of Newborn

Primary Atelectasis, In Perinatal Period

Primary Failure To Expand Terminal Respiratory Units

Immature Lungs

Primary Atelectasis

Pulmonary Immaturity Nos

Lung Lobe Hypoplasia, Associated With Short Gestation

Lung Nonexpansion

Premature Lungs

Pulmonary Hypoplasia Associated With Short Gestation

Failure Of Expansion Of Terminal Respiratory Units

Primary Atelectasis Of Fetus Or Newborn

Primary Atelectasis In Perinatal Period
Scoliosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06920 IRX1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06922 IRX3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus IRX1 VGNC VGNC:30286
Felis catus IRX1 VGNC VGNC:102235
Mus musculus IRX1 MGD MGI:1197515
Macaca mulatta IRX1 VGNC VGNC:73591
Rattus norvegicus IRX1 RGD RGD:1309060
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