2. Gene
  3. HKDC1 - hexokinase domain containing 1 Gene

HKDC1 - hexokinase domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含己糖激酶结构域 1

种属: Homo sapiens

同用名: RP92

基因 ID: 80201 | 基因类型: protein coding

关于 HKDC1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,220,332-69,267,552 (from NCBI)

This gene has 3 transcripts (splice variants), 178 orthologues, 4 paralogues and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 22.5), small intestine (RPKM 21.3) and 6 other tissues.

功能概要

该基因编码己糖激酶蛋白家族的一个成员。编码的蛋白质参与葡萄糖代谢，表达减少可能与妊娠糖尿病有关。该基因的高表达也可能与肝癌的不良预后有关。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the Hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016]

HKDC1 基因产物(1)

mRNA Protein Name
NM_025130.4 NP_079406.4 hexokinase HKDC1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glucokinase activity IDA
IDA: 通过直接分析推断
30517626 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glucose 6-phosphate metabolic process IDA
IDA: 通过直接分析推断
30517626 GOA
involved in intracellular glucose homeostasis IDA
IDA: 通过直接分析推断
30517626 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
30085091 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
30517626 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HKDC1 蛋白结构

Hexokinase_1

Hexokinase_1: Hexokinase (17 - 221)

Hexokinase_2

Hexokinase_2: Hexokinase (224 - 462)

Hexokinase_1

Hexokinase_1: Hexokinase (465 - 668)

Hexokinase_2

Hexokinase_2: Hexokinase (670 - 909)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 917 a.a.
蛋白主名 其他名称

hexokinase HKDC1

hexokinase domain-containing protein 1

HKDC1 抗体

目录号 产品名 应用 反应物种
HY-P83243 HKDC1 Antibody (YA2988) WB, IP Human
HY-P83243A HKDC1 Antibody (YA2988)(PBS only) WB, IP Human

关联疾病

疾病名称 别名
Retinitis Pigmentosa 92

RP92

Retinitis Pigmentosa, Type 92
Orofacial Cleft 1

OFC1

Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 1

Orofacial Cleft, Nonsyndromic

Ofc

Cleft Lip/Palate, Nonsyndromic

Orofacial Cleft-1

Nonsyndromic Cleft Lip With Or Without Cleft Palate 1

Nonsyndromic Cleft Lip Palate

Otofaciocervical Syndrome 1
Gestational Diabetes

Gestational Diabetes Mellitus

GDM

Diabetes Mellitus Arising In Pregnancy

Maternal Gestational Diabetes Mellitus

Diabetes Mellitus, Gestational

Diabetes Mellitus, Pregnancy Related

Diabetes, Pregnancy-Induced

Diabetes Gestational

Diabetes, Gestational

Diabetes Of Pregnancy

Gdm - [Gestational Diabetes Mellitus]

Gestational Diabetes Mellitus Nos

Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Retinitis Pigmentosa 73

RP73

Retinitis Pigmentosa, Type 73
Diabetes Mellitus

Diabetes
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06195 HKDC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19441 Hkdc1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25933 Hkdc1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris HKDC1 VGNC VGNC:41701
Macaca mulatta HKDC1 VGNC VGNC:73432
Mus musculus HKDC1 MGD MGI:2384910
Rattus norvegicus HKDC1 RGD RGD:2321830
Bos taurus HKDC1 VGNC VGNC:29867
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