2. Gene
  3. Dhx58 - DEXH (Asp-Glu-X-His) box polypeptide 58 Gene

Dhx58 - DEXH (Asp-Glu-X-His) box polypeptide 58 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: LPG2; Lgp2; RLR-3; D11Lgp2e; B430001I08Rik

基因 ID: 80861 | 基因类型: protein coding

关于 Dhx58

功能概要

Enables double-stranded RNA binding activity. Involved in several processes, including negative regulation of innate immune response; regulation of type I interferon production; and regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DHX58 (DExH-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]

Dhx58 基因产物(1)

mRNA Protein Name
NM_030150.2 NP_084426.2 ATP-dependent RNA helicase DHX58
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
21703541 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of RIG-I signaling pathway IMP
IMP: 通过突变表型推断
17475874 MGI
involved in negative regulation of innate immune response IMP
IMP: 通过突变表型推断
21525357 MGI
involved in negative regulation of type I interferon production IMP
IMP: 通过突变表型推断
21525357 MGI
involved in positive regulation of MDA-5 signaling pathway IMP
IMP: 通过突变表型推断
20080593 MGI
involved in positive regulation of RIG-I signaling pathway IMP
IMP: 通过突变表型推断
20080593 MGI
involved in positive regulation of type I interferon production IMP
IMP: 通过突变表型推断
20080593 MGI
acts upstream of or within response to bacterium IEP
IEP: 通过表达模式推断
23012479 MGI
involved in response to virus IMP
IMP: 通过突变表型推断
20080593 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11735219 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ATP-dependent RNA helicase DHX58

probable ATP-dependent RNA helicase DHX58

ATP-dependent helicase LGP2

RIG-I-like receptor 3

RIG-I-like receptor Lgp2

RLR

RNA helicase LGP2

probable ATP-dependent helicase LGP2

protein D11Lgp2

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03759 DHX58 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21554 Dhx58 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dhx58 NCBI NCBI:79132
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