2. Gene
  3. Lyn - LYN proto-oncogene, Src family tyrosine kinase Gene

Lyn - LYN proto-oncogene, Src family tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: p53Lyn; p56Lyn

基因 ID: 81515 | 基因类型: protein coding

关于 Lyn

功能概要

Enables several functions, including gamma-tubulin binding activity; signaling receptor binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including histamine secretion by mast cell; neurogenesis; and positive regulation of Fc receptor mediated stimulatory signaling pathway. Located in several cellular components, including adherens junction; mitochondrial envelope; and postsynaptic density. Part of Integrin alpha2-beta1 complex. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Biomarker of Parkinsonism and endometriosis. Orthologous to human Lyn (Lyn proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lyn 基因产物(2)

mRNA Protein Name
NM_001111098.1 NP_001104568.1 tyrosine-protein kinase Lyn isoform B
NM_030857.2 NP_110484.1 tyrosine-protein kinase Lyn isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
8190127 RGD
enables gamma-tubulin binding IDA
IDA: 通过直接分析推断
10545487 RGD
enables glycosphingolipid binding IPI
IPI: 通过物理相互作用推断
8106508 RGD
enables integrin binding IDA
IDA: 通过直接分析推断
15504915 RGD
enables phosphoprotein binding IPI
IPI: 通过物理相互作用推断
8910399 RGD
enables platelet-derived growth factor receptor binding IPI
IPI: 通过物理相互作用推断
15504915 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10944523 RGD
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
12007793 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
17579026 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
12681493 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
8870703 RGD
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
14531861 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to heat IEP
IEP: 通过表达模式推断
12372808 RGD
involved in histamine secretion by mast cell IMP
IMP: 通过突变表型推断
16177098 RGD
involved in oligodendrocyte development IEP
IEP: 通过表达模式推断
15504915 RGD
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway IMP
IMP: 通过突变表型推断
16177098 RGD
involved in positive regulation of glial cell proliferation IDA
IDA: 通过直接分析推断
15504915 RGD
involved in positive regulation of oligodendrocyte progenitor proliferation IMP
IMP: 通过突变表型推断
15504915 RGD
involved in positive regulation of phosphorylation IMP
IMP: 通过突变表型推断
16177098 RGD
involved in regulation of release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
16177098 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
16529858 RGD
involved in response to axon injury IEP
IEP: 通过表达模式推断
17918263 RGD
involved in response to carbohydrate IEP
IEP: 通过表达模式推断
10330413 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
12089355 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
15287886 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
16713446 RGD
involved in response to sterol depletion IEP
IEP: 通过表达模式推断
10330413 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
16529858 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17039281 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
1709169 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
14529711 RGD
part of integrin alpha2-beta1 complex IDA
IDA: 通过直接分析推断
18234883 RGD
located in mitochondrial crista IDA
IDA: 通过直接分析推断
12007793 RGD
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
12007793 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10545487 RGD
is active in postsynaptic specialization, intracellular component IDA
IDA: 通过直接分析推断
14529711 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase Lyn

Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

lyn protein non-receptor kinase

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-176194 Antifibrotic agent 1 Inhibitor / 否
HY-175437 MRT-7612 Degrader / 否
HY-178014 SIK1-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lyn NCBI NCBI:4067
Macaca fascicularis Lyn NCBI NCBI:102118154
Mus musculus Lyn NCBI NCBI:17096
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