2. Gene
  3. NETO2 - neuropilin and tolloid like 2 Gene

NETO2 - neuropilin and tolloid like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：neuropilin 和 tolloid 样 2

种属: Homo sapiens

同用名: BTCL2; NEOT2

基因 ID: 81831 | 基因类型: protein coding

关于 NETO2

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:47,077,703-47,143,945 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 35 paralogues. Broad expression in spleen (RPKM 8.8), brain (RPKM 6.7) and 17 other tissues.

功能概要

该基因编码一种预测的跨膜蛋白，该蛋白包含两个细胞外 CUB 结构域，后跟一个低密度脂蛋白 A 类 (LDLa) 结构域。大鼠中的一个类似基因编码一种蛋白质，该蛋白质通过调节红藻氨酸受体功能来调节大脑中的谷氨酸信号。该基因的表达可能是增殖性婴儿血管瘤的生物标志物。该基因的假基因位于 8 号染色体的长臂上。已观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 1 月]

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating Kainate Receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

NETO2 基因产物(2)

mRNA Protein Name
NM_001201477.2 NP_001188406.1 neuropilin and tolloid-like protein 2 isoform 2 precursor
NM_018092.5 NP_060562.3 neuropilin and tolloid-like protein 2 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NETO2 蛋白结构

CUB

CUB: CUB domain (45 - 156)

CUB

CUB: CUB domain (181 - 287)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (296 - 331)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 525 a.a.
蛋白主名 其他名称

neuropilin and tolloid-like protein 2

brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2

关联疾病

疾病名称 别名
Cataract 4, Multiple Types

Cataract 4 Multiple Types

CTRCT4

Cca3

Pcc

Aculeiform Cataract

Cataract 4, Multiple Types, With Or Without Microcornea

Cataract, Crystalline Aculeiform

Caca

Cataract, Congenital, Cerulean Type, 3

Congenital Cataract Cerulean Type 3

Cataract Congenital Dominant Non Nuclear

Ccp

Cataract, Nonnuclear Polymorphic Congenital

Cataract, Punctate, Progressive Juvenile-Onset

Cataract 4 Multiple Types With Or Without Microcornea

Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

Cataract, Polymorphic Congenital

Congenital Cataract Blue Dot Type 3

Congenital Non-Nuclear Polymorphic Cataract

Crystalline Aculeiform Cataract

Punctate, Progressive Juvenile-Onset, Cataract

Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09214 NETO2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NETO2 VGNC VGNC:43749
Bos taurus NETO2 VGNC VGNC:32012
Macaca mulatta NETO2 VGNC VGNC:99526
Rattus norvegicus NETO2 RGD RGD:1305310
Mus musculus NETO2 MGD MGI:1921763
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