2. Gene
  3. Cdh2 - cadherin 2 Gene

Cdh2 - cadherin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: N-cadherin

基因 ID: 83501 | 基因类型: protein coding

关于 Cdh2

功能概要

Enables beta-catenin binding activity; nitric-oxide synthase binding activity; and protein kinase binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; regulation of glutamatergic synaptic transmission; and regulation of myelination. Located in several cellular components, including T-tubule; adherens junction; and fascia adherens. Is integral component of postsynaptic specialization membrane and integral component of presynaptic active zone membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (Cadherin 2). [provided by Alliance of Genome Resources, Apr 2022]

Cdh2 基因产物(1)

mRNA Protein Name
NM_031333.2 NP_112623.2 cadherin-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
12533412 RGD
enables nitric-oxide synthase binding IPI
IPI: 通过物理相互作用推断
15858215 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10753743 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
12700184 RGD
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
12700184 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
8834786 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: 通过突变表型推断
11414796 RGD
involved in cell-cell adhesion IDA
IDA: 通过直接分析推断
12533412 RGD
involved in modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
9655504 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
9655504 RGD
involved in regulation of Rho protein signal transduction IMP
IMP: 通过突变表型推断
16515795 RGD
involved in regulation of axonogenesis IMP
IMP: 通过突变表型推断
12657688 RGD
involved in regulation of myelination IMP
IMP: 通过突变表型推断
11414796 RGD
involved in regulation of protein localization IMP
IMP: 通过突变表型推断
16515795 RGD
involved in synapse assembly IMP
IMP: 通过突变表型推断
12125071 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in T-tubule IDA
IDA: 通过直接分析推断
15579534 RGD
located in adherens junction IDA
IDA: 通过直接分析推断
8834786 RGD
located in desmosome IDA
IDA: 通过直接分析推断
21617128 RGD
located in fascia adherens IDA
IDA: 通过直接分析推断
16515795 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
9655504 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
9655504 RGD
located in intercalated disc IDA
IDA: 通过直接分析推断
15579534 RGD
located in membrane IDA
IDA: 通过直接分析推断
19723622 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
18179895 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
12533412 RGD
located in synapse IDA
IDA: 通过直接分析推断
18179895 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cadherin-2

cadherin 2, type 1, N-cadherin (neuronal)

neural cadherin

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02330 CDH2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17634 Cdh2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24094 Cdh2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdh2 NCBI NCBI:1000
Mus musculus Cdh2 NCBI NCBI:12558
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