Timeless - timeless circadian regulator Gene

种属: Rattus norvegicus

同用名: Tim; rTIM; rTLP

关于 Timeless

功能概要

The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA Polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the Period genes (Per1, Per2, and Per3) and Others to downregulate activation of Per1 by Clock/Arntl. Changes in this gene or its expression may promote prostate Cancer, lung Cancer, breast Cancer, and mental disorders. [provided by RefSeq, Feb 2014]