2. Gene
  3. Cit - citron rho-interacting serine/threonine kinase Gene

Cit - citron rho-interacting serine/threonine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: CRIK

基因 ID: 83620 | 基因类型: protein coding

关于 Cit

功能概要

Predicted to enable several functions, including PDZ domain binding activity; scaffold protein binding activity; and transcription coactivator binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; liver development; and regulation of actin polymerization or depolymerization. Located in several cellular components, including Golgi cisterna; cleavage furrow; and midbody. Used to study epilepsy; microcephaly; and visual epilepsy. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Cit 基因产物(1)

mRNA Protein Name
NM_001029911.1 NP_001025082.1 citron rho-interacting kinase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
9870942 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
12411428 RGD
involved in Golgi organization IMP
IMP: 通过突变表型推断
14595335 RGD
involved in gamma-aminobutyric acid signaling pathway IDA
IDA: 通过直接分析推断
9870942 RGD
involved in liver development IEP
IEP: 通过表达模式推断
12411428 RGD
involved in postsynaptic cytoskeleton organization IDA
IDA: 通过直接分析推断
9870942 RGD
involved in postsynaptic density protein 95 clustering IDA
IDA: 通过直接分析推断
9870942 RGD
involved in regulation of actin polymerization or depolymerization IDA
IDA: 通过直接分析推断
14595335 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in GABA-ergic synapse IDA
IDA: 通过直接分析推断
9870942 RGD
located in Golgi cisterna IDA
IDA: 通过直接分析推断
14595335 RGD
located in cleavage furrow IDA
IDA: 通过直接分析推断
11932363 RGD
located in glutamatergic postsynaptic density IDA
IDA: 通过直接分析推断
9870942 RGD
located in midbody IDA
IDA: 通过直接分析推断
17534152 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
14595335 RGD
located in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
9870942 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

citron rho-interacting kinase

citron (rho-interacting, serine/threonine kinase 21)

citron Rho-interacting kinase

citron kinase

citron-K kinase

postsynaptic density protein (citron)

rho-interacting, serine/threonine-protein kinase 21

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99016A Enfortumab vedotin-ejfv Inhibitor 99.69% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-160441 MC-Val-Cit-PAB-Ispinesib Inhibitor 99.85% Phase 3
HY-P99612 Farletuzumab ecteribulin 99.40% Phase 2
Pre-clinical Phase
生物活性分子 (228)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15575 VcMMAE Inhibitor 99.97% 否
HY-20336 Mc-Val-Cit-PABC-PNP 98.75% 否
HY-100374 Val-Cit-PAB-MMAE 99.98% 否
HY-78738 MC-Val-Cit-PAB 99.88% 否
HY-112786 MC-Val-Cit-PAB-MMAF 99.25% 否
HY-145929 MC-Val-Cit-PAB-Exatecan Inhibitor 99.57% 否
HY-41189 Fmoc-Val-Cit-PAB-PNP 99.60% 否
HY-12362 Val-cit-PAB-OH 99.64% 否
HY-15575G VcMMAE (GMP) / 否
HY-130990 DBCO-PEG4-Val-Cit-PAB-MMAF 98.69% 否
HY-19318 Fmoc-Val-Cit-PAB 99.75% 否
HY-131296 5-A-RU-PABC-Val-Cit-Fmoc 98.98% 否
HY-139642 Mal-(CH2)5-Val-Cit-PAB-Eribulin 99.01% 否
HY-141156 Mal-PEG8-Val-Cit-PAB-MMAE 97.12% 否
HY-141154 Amino-PEG4-Val-Cit-PAB-MMAE 99.93% 否
HY-130989 SuO-Glu-Val-Cit-PAB-MMAE 99.38% 否
HY-141142 Boc-Val-Cit-PAB-PNP 99.55% 否
HY-78736 Val-Cit-PAB-OSBT 99.77% 否
HY-W038702 Boc-Val-Cit-OH ≥98.0% 否
HY-Y1191 EEDQ Antagonist 99.97% 否
HY-141155 endo-BCN-PEG4-Val-Cit-PAB-MMAE 98.84% 否
HY-141833 Bi-Mc-VC-PAB-MMAE 98.43% 否
HY-100566 SuO-Val-Cit-PAB-MMAE 98.0% 否
HY-130937 DBCO-Val-Cit-PABC-PNP 97.74% 否
HY-140150 Azido-PEG3-Val-Cit-PAB-PNP 99.21% 否
HY-W591408 DBCO-Val-Cit-PAB-MMAE 98.33% 否
HY-W008064 Fmoc-Cit-OH 99.32% 否
HY-148875 Py-MAA-Val-Cit-PAB-MMAE 98.46% 否
HY-140145 Mal-PEG4-Val-Cit-PAB-PNP 98.48% 否
HY-19812 Acetylene-linker-Val-Cit-PABC-MMAE 95.21% 否
HY-100115 TA-02 Inhibitor 99.85% 否
HY-128904 MC-Val-Cit-PAB-duocarmycin chloride 99.04% 否
HY-128902 MC-Val-Cit-PAB-vinblastine 99.48% 否
HY-112099 Mc-Val-Cit-PAB-Cl 95.0% 否
HY-153031 Val-Cit-PAB-Exatecan Inhibitor 99.79% 否
HY-153263 (Aminooxy)acetamide-Val-Cit-PAB-MMAE 96.87% 否
HY-100567 MAL-di-EG-Val-Cit-PAB-MMAE 99.92% 否
HY-147286 Ac-Lys-Val-Cit-PABC-MMAE 99.94% 否
HY-136154 Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP 96.67% 否
HY-139726 Mal-PEG4-Val-Cit-PAB-MMAE 98.64% 否
HY-141141 Boc-Val-Cit-PAB 99.61% 否
HY-141860 PSMA-Val-Cit-PAB-MMAE 99.52% 否
HY-156758 Mal-PEG8-Val-Cit-PAB-MMAF 99.97% 否
HY-19697 Aminocaproyl-Val-Cit-PABC-MMAE 99.89% 否
HY-19813A mDPR-Val-Cit-PAB-MMAE TFA 98.36% 否
HY-W190943 Azido-PEG4-Val-Cit-PAB-MMAE 99.43% 否
HY-W190927 MC-Val-Cit-Doxorubicin 99.67% 否
HY-112100 MC-Val-Cit-PAB-PROTAC ERα Degrader-1 Inhibitor 99.18% 否
HY-155052A PAD4-IN-2 TFA Inhibitor 95.64% 否
HY-128711 MAL-di-EG-Val-Cit-PAB-MMAF 98.56% 否
HY-140014 Val-Cit 99.76% 否
HY-172287 DBCO-PEG2-Val-Cit-PAB-MMAE 99.27% 否
HY-P4160 PDC31 Inhibitor / 否
HY-44177 Val-Cit-PAB-MMAF sodium 98.97% 否
HY-153373 4A3-Cit 98.04% 否
HY-Z0922 (R,R)-MC-Val-Cit-PAB Control 98.1% 否
HY-19811 Fmoc-Val-Cit-PAB-MMAE Inhibitor 98.85% 否
HY-15742 Vc-MMAD Inhibitor 99.96% 否
HY-130923 BCN-PEG1-Val-Cit-PABC-OH 95.0% 否
HY-130944 Mal-PEG1-Val-Cit-PABC-OH 95.12% 否
HY-136100A TCO-PEG1-Val-Cit-PABC-PNP TFA 99.69% 否
HY-138106 Fmoc-D-Cit-OH / 否
HY-148245 OH-Glu-Val-Cit-PAB-MMAE 99.03% 否
HY-15575S VcMMAE-d8 Inhibitor 97.56% 否
HY-153031A Val-Cit-PAB-Exatecan TFA Inhibitor 99.73% 否
HY-W190913 DBCO-PEG4-Val-Cit-PAB-PNP 98.28% 否
HY-140147 Mal-amido-PEG2-Val-Cit-PAB-PNP 98.40% 否
HY-160774 Val-Cit-PABC-DOX Inhibitor 95.06% 否
HY-171931A Aminocaproyl-Val-Cit-PABC-Exatecan TFA Inhibitor 99.18% 否
HY-W016733 D-Citrulline Modulator 98.0% 否
HY-126532 Fmoc-Val-Cit-PAB-Duocarmycin TM 99.0% 否
HY-131156 Mal-PEG2-Val-Cit-PABA-PNP 96.82% 否
HY-126672 Mal-amide-PEG4-Val-Cit-PAB-OH 99.12% 否
HY-128908 MC-Val-Cit-PAB-Indibulin 95.82% 否
HY-130222 Mal-PEG2-Val-Cit-PAB-OH 99.49% 否
HY-140144 Mal-PEG1-Val-Cit-PAB-PNP 98.41% 否
HY-147021 MC-Val-D-Cit-PAB-PNP 98.08% 否
HY-173161 Mc-d-Val-d-Cit-PAB-PNP 98.80% 否
HY-128899 MC-Val-Cit-PAB-Auristatin E 96.97% 否
HY-128906 MC-Val-Cit-PAB-Retapamulin 99.00% 否
HY-128909 MC-Val-Cit-PAB-rifabutin 95.33% 否
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% 否
HY-157763 Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 Degrader / 否
HY-177578 NN3201 99.15% 否
HY-100374G Val-Cit-PAB-MMAE (GMP) / 否
HY-128903 MC-Val-Cit-PAB-carfilzomib iodide 95.22% 否
HY-128907 MC-Val-Cit-PAB-clindamycin 99.99% 否
HY-130966 TCO-PEG1-Val-Cit-PABC-OH 99.14% 否
HY-136106 Fmoc-Gly3-Val-Cit-PAB 95.0% 否
HY-140143 Mal-PEG4-Val-Cit-PAB-OH 96.92% 否
HY-140149 Azido-PEG4-Val-Cit-PAB-OH 98.0% 否
HY-145489 Mal-PEG2-Val-Cit-PABA 98.91% 否
HY-145960A MC-Val-Cit-PAB-Amide-TLR7 agonist 4 formic Agonist 97.70% 否
HY-147286A Ac-Lys-Val-Cit-PABC-MMAE formic 99.96% 否
HY-148871 Mc-Val-Cit-PAB-Gefitinib chloride 98.69% 否
HY-155052 PAD4-IN-2 Inhibitor / 否
HY-156897 Val-Cit-amide-Ph-Maytansine 98.01% 否
HY-160694 cBu-Cit-GAL-02-221 Degrader / 否
HY-171931 Aminocaproyl-Val-Cit-PABC-Exatecan Inhibitor / 否
HY-177146 Paclitaxel-MVCP / 否
HY-177599 Boc-Val-Cit-PAB-MMAE 99.72% 否
HY-177681 N-(Mal)-N-(PEG8-Val-Cit-PAB-MMAE)-N-(PEG8-Val-Cit-PAB-Exatecan) / 否
HY-177879 2-MSP-5-HA-VA-PAB-Exatecan Inhibitor 97.96% 否
HY-178219 Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE 97.88% 否
HY-19318A Fmoc-Val-D-Cit-PAB / 否
HY-19318B Fmoc-D-Val-Cit-PAB / 否
HY-19318C Fmoc-D-Val-D-Cit-PAB 98.97% 否
HY-204602 Fmoc-Val-Cit-PAB-MMAF-OtBu / 否
HY-78738G MC-Val-Cit-PAB (GMP) / 否
HY-P5372A Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA Agonist 99.78% 否
HY-W590556 Endo-BCN-PEG4-Val-Cit-PAB-MMAF / 否
HY-151726 Azido-PEG(4)-Val-Cit-PAB-PNP 98.05% 否
HY-126492 Vat-Cit-PAB-Monomethyl Dolastatin 10 / 否
HY-128893 MC-Sq-Cit-PAB-Gefitinib / 否
HY-128905 MC-Val-Cit-PAB-dimethylDNA31 99.97% 否
HY-101909 Val-Cit-PAB-MMAF / 否
HY-111121 cBu-Cit-OH / 否
HY-12362G Val-cit-PAB-OH (GMP) / 否
HY-126533 PDP-C1-Ph-Val-Cit / 否
HY-126667 SC-Val-Cit-PAB / 否
HY-126670 mDPR(Boc)-Val-Cit-PAB / 否
HY-126671 Mal-Phe-C4-Val-Cit-PAB / 否
HY-126674 Mal-Phe-C4-Val-Cit-PAB-DMEA / 否
HY-126676 DBCO-(PEG2-Val-Cit-PAB)2 / 否
HY-128894 MC-Sq-Cit-PAB-Dolastatin10 / 否
HY-130922 BCN-PEG1-Val-Cit-OH / 否
HY-130930 Acid-propionylamino-Val-Cit-OH / 否
HY-130934 TCO-PEG1-Val-Cit-OH / 否
HY-130935 DBCO-Val-Cit-OH / 否
HY-130936 DBCO-Val-Cit-PABC-OH / 否
HY-132973 MC-Val-Cit-PAB-NH-C2-NH-Boc 95.0% 否
HY-133459 Mal-PEG1-Val-Cit-OH / 否
HY-136034 Azido-PEG1-Val-Cit-OH / 否
HY-136098 DBCO-PEG4-acetic-Val-Cit-PAB 99.23% 否
HY-136100 TCO-PEG1-Val-Cit-PABC-PNP / 否
HY-136103 DBCO-PEG4-Propionic-Val-Cit-PAB / 否
HY-136105 Azido-PEG1-Val-Cit-PABC-PNP / 否
HY-136108 Fmoc-Gly3-Val-Cit-PAB-PNP / 否
HY-136137 Azide-PEG1-Val-Cit-PABC-OH / 否
HY-140146 Mal-amido-PEG2-Val-Cit-PAB-OH / 否
HY-140148 Azido-PEG3-Val-Cit-PAB-OH / 否
HY-141143 MC(C5)-Val-Cit / 否
HY-141144 OPSS-Val-Cit-PAB-OH / 否
HY-141145 OPSS-Val-Cit-PAB-PNP / 否
HY-142079 Br-C1-CONH-C5-CO-Val-Cit-PAB-MMAE / 否
HY-147021A MC-D-Val-Cit-PAB-PNP / 否
HY-148227 Mal-Cyclobutane-1,1-dicarboxamide-Cit-PAB-MMAE / 否
HY-148326 Glu(OtBu)-Val-Cit-PAB-OH / 否
HY-151700 6-Azidohexanoyl-Val-Cit-PAB / 否
HY-153236 Py-MAA-Val-Cit-PAB-DX8951 / 否
HY-156727 Val-Cit-PABC-Ahx-May / 否
HY-156727A Val-Cit-PABC-Ahx-May TFA / 否
HY-156896 Val-Cit-amide-Cbz-N(Me)-Maytansine 97.92% 否
HY-158135 Val-Cit-PAB-DEA-COOH / 否
HY-158137 Val-Cit-PAB-DEA-Dxd / 否
HY-158137A Val-Cit-PAB-DEA-Dxd TFA 99.11% 否
HY-159797 L-Val-D-Cit-PAB / 否
HY-160756 Val-Cit-Exatecan Inhibitor / 否
HY-160756A Val-Cit-Exatecan TFA / 否
HY-164303 Val-Cit-PAB-DEA-Duo-DM Inhibitor / 否
HY-164309 DBCO-PEG3-Glu-Val-Cit-PABC-MMAE 97.69% 否
HY-164310 TCO-PEG3-Glu-Val-Cit-PABC-MMAF Inhibitor / 否
HY-164346 Amine-PEG8-Val-Cit-PAB-MMAE Inhibitor / 否
HY-164380 MC-Val-Cit-Gly-exatecan-β-D-glucopyranosiduronic acid Ligand / 否
HY-171159 MC-Val-Cit-PAB-Sunitinib / 否
HY-172985 CIT-ALD / 否
HY-175881 3-Formyl-L-tyrosine-oxime-Val-Cit-PAPB / 否
HY-176202 TLR7/8 agonist 12-PAB-(PEG4-Me)-Cit-Val-PEG2-amide-C2-MC / 否
HY-177547 H-Cit-Lys(ma-Lys(PEG16))-Tyr-OH / 否
HY-177548 Fmoc-Val-Cit-PAB-Exatecan Inhibitor / 否
HY-177678 N-(Azido-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177679 N-(Amino-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177680 N-(Mal-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177682 N-(NHS-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177683 N-(DBCO-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177684 N-(endo-BCN-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177685 N-(TCO-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177686 N-(Azido-PEG4)-N-(PEG4-Val-Cit-PAB-MMAF)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177687 N-(Mal-PEG4)-N-(PEG4-Val-Cit-PAB-MMAF)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177688 N-(NHS-PEG4)-N-(PEG4-Val-Cit-PAB-MMAF)-N-(PEG4-Val-Cit-PAB-Exatecan) / 否
HY-177953 Mal-PEG2-Val-Arg-PABC-OMe-Eribulin / 否
HY-178489 BGC1614 / 否
HY-181911 L2-FK866 Inhibitor / 否
HY-181992 Mal-PEG4-Val-Cit-PAB-MSA-2 / 否
HY-19318G Fmoc-Val-Cit-PAB (GMP) / 否
HY-20336G Mc-Val-Cit-PABC-PNP (GMP) / 否
HY-78736G Val-Cit-PAB-OSBT (GMP) / 否
HY-E70937 Transcarbamylase, Streptococcus faecalis Ornithine / 否
HY-P10775 BT1769 Antagonist / 否
HY-P4007 [Pmp1,DTyr(OEt)2,Val4,Cit8] Vasopressin / 否
HY-P5372 Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 Agonist / 否
HY-P5836 Citrullinated LL-37 1cit Inhibitor / 否
HY-P5837 Citrullinated LL-37 2cit Inhibitor / 否
HY-P5838 Citrullinated LL-37 5cit Inhibitor / 否
HY-P5842 Citrullinated LL-37 3cit Inhibitor / 否
HY-P5843 Citrullinated LL-37 4cit Inhibitor / 否
HY-RS02727 CIT Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03728 DHDDS Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W591339 Mal-PEG8-Val-Cit-PAB-PNP / 否
HY-W800626 Boc-PEG6-Val-Cit-PAB-OH / 否
HY-W800847 Mal-Amide-PEG4-Val-Cit-PAB-PNP / 否
HY-151699 6-Azidohexanoyl-Val-Cit-PAB-PNP / 否
HY-151709 N3-L-Cit-OH / 否
HY-151709A N3-L-Cit-OH (DCHA) / 否
HY-152919 Mal-amide-PEG8-Val-Cit-PAB-OH / 否
HY-164273 Azidoacetyl-Val-Cit-PAB-OH / 否
HY-164275 Alkyne-Val-Cit-PAB-OH / 否
HY-171663 Mal-Cyclobutane-1,1-dicarboxamide-Cit-PAB carbonic acid / 否
HY-172291 Mal-amide-PEG8-Val-Cit-PAB-PNP / 否
HY-176478 PAB-(PEG4-Me)-Cit-Val-PEG2-amide-C2-MC / 否
HY-177502 NHS-cBu-Cit-PAB / 否
HY-177503 cBu-Cit-PAB / 否
HY-RS16962 Cit Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23405 Cit Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W141765 Fmoc-Cit-PAB-OH 98.58% 否
HY-W591286 Alkyne-Val-Cit-PAB-PNP / 否
HY-W591440 Fmoc-Cit-PAB-PNP / 否
HY-W800617 NH2-PEG1-Val-Cit-PAB-OH / 否
HY-W800618 NH2-PEG3-Val-Cit-PAB-OH / 否
HY-W800619 NH2-PEG4-Val-Cit-PAB-OH / 否
HY-W800620 NH2-PEG6-Val-Cit-PAB-OH / 否
HY-W800621 Fmoc-PEG2-Val-Cit-PAB-OH / 否
HY-W800622 Fmoc-PEG4-Val-Cit-PAB-OH / 否
HY-W800623 Fmoc-PEG6-Val-Cit-PAB-OH / 否
HY-W800624 Boc-PEG2-Val-Cit-PAB-OH / 否
HY-W800625 Boc-PEG4-Val-Cit-PAB-OH / 否
HY-W800814 Azido-PEG8-Amido-Val-Cit-PAB / 否
HY-W800837 t-Boc-N-amido-PEG4-Val-Cit / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99016B Enfortumab vedotin-ejfv (solution) Inhibitor 99.78% 否
HY-164154 ADC Control Human IgG1-vcMMAF Inhibitor 97.28% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cit NCBI NCBI:11113
Macaca fascicularis Cit NCBI NCBI:102134813
Mus musculus Cit NCBI NCBI:12704
Macaca mulatta Cit NCBI NCBI:695846
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