ARMC10 - armadillo repeat containing 10 Gene

中文名称：含犰狳重复 10

种属: Homo sapiens

同用名: SVH; PNAS112; PNAS-112; PSEC0198

关于 ARMC10

功能概要

该基因编码的蛋白质包含犰狳重复序列和跨膜结构域。编码的蛋白质通过与 p53 的 DNA 结合域直接相互作用降低肿瘤抑制蛋白 p53 的转录活性，并可能在细胞生长和存活中发挥作用。该基因的上调可能在肝细胞癌中起作用。已经观察到该基因编码多种亚型的选择性剪接转录变体，并且该基因的假基因位于 3 号染色体的长臂上。[RefSeq 提供，2011 年 9 月]

This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]