1. Gene
  2. NLRC5 - NLR family CARD domain containing 5 Gene

NLRC5 - NLR family CARD domain containing 5 Gene

中文名称:含 NLR 家族 CARD 结构域 5

种属: Homo sapiens

同用名: NOD4; NOD27; CLR16.1

基因 ID: 84166 | 基因类型: protein coding

关于 NLRC5

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,989,557-57,083,520 (from NCBI)

This gene has 29 transcripts (splice variants), 169 orthologues and 20 paralogues. Broad expression in spleen (RPKM 23.6), lymph node (RPKM 20.1) and 22 other tissues.

功能概要

该基因编码含有半胱天冬酶募集结构域的 NLR 家族成员。该基因通过抑制 NF-kappa-B 激活和负调节 I 型干扰素信号通路,在细胞因子反应和抗病毒免疫中发挥作用。[RefSeq 提供,2011 年 10 月]

This gene encodes a member of the Caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and Antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]

NLRC5 基因产物(26)

mRNA Protein Name
NM_001330552.2 NP_001317481.1 protein NLRC5 isoform 2
NM_001384950.1 NP_001371879.1 protein NLRC5 isoform 1
NM_001384951.1 NP_001371880.1 protein NLRC5 isoform 2
NM_001384952.1 NP_001371881.1 protein NLRC5 isoform 3
NM_001384953.1 NP_001371882.1 protein NLRC5 isoform 3
NM_001384954.1 NP_001371883.1 protein NLRC5 isoform 4
NM_001384955.1 NP_001371884.1 protein NLRC5 isoform 5
NM_001384956.1 NP_001371885.1 protein NLRC5 isoform 6
NM_001384957.1 NP_001371886.1 protein NLRC5 isoform 7
NM_001384958.1 NP_001371887.1 protein NLRC5 isoform 8
NM_001384959.1 NP_001371888.1 protein NLRC5 isoform 9
NM_001384960.1 NP_001371889.1 protein NLRC5 isoform 10
NM_001384961.1 NP_001371890.1 protein NLRC5 isoform 11
NM_001384962.1 NP_001371891.1 protein NLRC5 isoform 11
NM_001384963.1 NP_001371892.1 protein NLRC5 isoform 12
NM_001384964.1 NP_001371893.1 protein NLRC5 isoform 12
NM_001384965.1 NP_001371894.1 protein NLRC5 isoform 13
NM_001384966.1 NP_001371895.1 protein NLRC5 isoform 14
NM_001384967.1 NP_001371896.1 protein NLRC5 isoform 15
NM_001384968.1 NP_001371897.1 protein NLRC5 isoform 16
NM_001384969.1 NP_001371898.1 protein NLRC5 isoform 17
NM_001384970.1 NP_001371899.1 protein NLRC5 isoform 18
NM_001384971.1 NP_001371900.1 protein NLRC5 isoform 19
NM_001384972.1 NP_001371901.1 protein NLRC5 isoform 20
NM_001384973.1 NP_001371902.1 protein NLRC5 isoform 21
NM_032206.5 NP_115582.4 protein NLRC5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20639463 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20434986 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
20061403 GOA
located in cytosol IDA
IDA: 通过直接分析推断
20639463 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20639463 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NLRC5 蛋白结构

NACHT

NACHT: NACHT domain (222 - 382)

LRR_6

LRR_6: Leucine Rich repeat (870 - 891)

LRR_6

LRR_6: Leucine Rich repeat (1008 - 1026)

LRR_6

LRR_6: Leucine Rich repeat (1521 - 1542)

LRR_6

LRR_6: Leucine Rich repeat (1578 - 1599)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (1606 - 1648)

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  • 1500
  • 1866 a.a.
蛋白主名 其他名称

protein NLRC5

NOD-like receptor C5

关联疾病

疾病名称 别名
Pityriasis Rubra Pilaris

PRP

Devergie'S Disease

Prp - [Pityriasis Rubra Pilaris]

Familial Pityriasis Rubra Pilaris

Familial Prp

Pityriasis Rubra Pilaris--Familial Type

Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos

Familial Mediterranean Fever

Periodic Fever Syndrome

FMF

Benign Paroxysmal Peritonitis

Periodic Disease

Recurrent Polyserositis

Familial Paroxysmal Polyserositis

Periodic Fever

Familial Mediterranean Fever, Autosomal Recessive

Familial Mediterranean Fever, Ar

Polyserositis, Recurrent

Polyserositis, Familial Paroxysmal

Periodic Peritonitis

Mef

Reimann Periodic Disease

Siegal-Cattan-Mamou Disease

Wolff Periodic Disease

Benign Recurrent Polyserositis

Mediterranean Fever, Familial

ARFMF

Autosomal Recessive Familial Mediterranean Fever

Fever, Mediterranean, Familial, Autosomal Recessive

Hereditary Autoinflammatory Diseases

Fmf - [Familial Mediterranean Fever]

Periodic Polyserositis

Periodic Familial Polyserositis

Periodic Familial Peritonitis

Paroxysmal Polyserositis

Hereditary Amyloid Nephropathy

Familial Recurrent Polyserositis

Familial Non-Neuropathic Amyloidosis

Armenian Disease

Riemann Periodic Disease

Siegal Cattan Mamou Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NLRC5 RGD RGD:1309166
Canis familiaris NLRC5 VGNC VGNC:43844
Felis catus NLRC5 VGNC VGNC:63828
Macaca mulatta NLRC5 VGNC VGNC:75285
Bos taurus NLRC5 VGNC VGNC:32114
Mus musculus NLRC5 MGD MGI:3612191