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  2. ADGRA1 - adhesion G protein-coupled receptor A1 Gene

ADGRA1 - adhesion G protein-coupled receptor A1 Gene

中文名称:粘附 G 蛋白偶联受体 A1

种属: Homo sapiens

同用名: GPR123

基因 ID: 84435 | 基因类型: protein coding

关于 ADGRA1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,087,924-133,131,675 (from NCBI)

This gene has 2 transcripts (splice variants), 189 orthologues and 42 paralogues. Biased expression in brain (RPKM 3.7), adrenal (RPKM 1.0) and 1 other tissue.

功能概要

该基因编码的蛋白质属于 G 蛋白偶联受体的粘附家族。这个家族的成员在几个感觉系统中发挥作用,调节血压、免疫反应、食物摄入和发育。啮齿动物中的一种类似蛋白质被认为在调节神经元信号通路中发挥作用。已经描述了该基因的几种可变剪接的转录本变体,但尚未确定其中一些变体的全长性质。[RefSeq 提供,2014 年 3 月]

This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of Neuronal Signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]

ADGRA1 基因产物(2)

mRNA Protein Name
NM_001083909.3 NP_001077378.1 adhesion G protein-coupled receptor A1 isoform 1
NM_001291085.2 NP_001278014.1 adhesion G protein-coupled receptor A1 isoform 2

ADGRA1 蛋白结构

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (22 - 302)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 560 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor A1

G-protein coupled receptor 123

关联疾病

疾病名称 别名
Usher Syndrome, Type Iic

Usher Syndrome Type 2c

USH2C

Usher Syndrome, Type 2c

Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

Usher Syndrome Type Iic

Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

Usher Syndrome 2c

Usher'S Syndrome Type 2c

Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect

Usher Syndrome Type 2

Ush2

Usher Syndrome Type Ii

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADGRA1 RGD RGD:1308241
Mus musculus ADGRA1 MGD MGI:1277167
Bos taurus ADGRA1 VGNC VGNC:55933
Canis familiaris ADGRA1 VGNC VGNC:56110
Macaca mulatta ADGRA1 VGNC VGNC:100291