1. Gene
  2. FBXL20 - F-box and leucine rich repeat protein 20 Gene

FBXL20 - F-box and leucine rich repeat protein 20 Gene

中文名称:F-box 和富亮氨酸的重复蛋白 20

种属: Homo sapiens

同用名: Fbl2; Fbl20

基因 ID: 84961 | 基因类型: protein coding

关于 FBXL20

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,252,663-39,402,556 (from NCBI)

This gene has 6 transcripts (splice variants), 241 orthologues and 15 paralogues. Ubiquitous expression in testis (RPKM 3.5), brain (RPKM 3.2) and 25 other tissues.

功能概要

F-box 蛋白家族的成员,例如 FBXL20,以大约 40 个氨基酸的 F-box 基序为特征。由 SKP1 (MIM 601434) 、cullin (参见 CUL1;MIM 603134) 和 F-box 蛋白形成的 SCF 复合物充当蛋白质-泛素连接酶。 F-box 蛋白通过 F-box 与 SKP1 相互作用,并且它们通过其他蛋白质相互作用域与泛素化目标相互作用 (Jin 等人,2004 [PubMed 15520277]) 。[OMIM 提供,2008 年 3 月]

Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXL20 基因产物(4)

mRNA Protein Name
NM_001184906.2 NP_001171835.1 F-box/LRR-repeat protein 20 isoform 2
NM_001370208.3 NP_001357137.2 F-box/LRR-repeat protein 20 isoform 3
NM_001370209.3 NP_001357138.2 F-box/LRR-repeat protein 20 isoform 4
NM_032875.3 NP_116264.2 F-box/LRR-repeat protein 20 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
27705803 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FBXL20 蛋白结构

F-box-like

F-box-like: F-box-like (27 - 70)

LRR_6

LRR_6: Leucine Rich repeat (116 - 133)

LRR_6

LRR_6: Leucine Rich repeat (142 - 165)

LRR_6

LRR_6: Leucine Rich repeat (168 - 190)

LRR_6

LRR_6: Leucine Rich repeat (220 - 243)

LRR_6

LRR_6: Leucine Rich repeat (246 - 270)

LRR_6

LRR_6: Leucine Rich repeat (324 - 348)

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  • 436 a.a.
蛋白主名 其他名称

F-box/LRR-repeat protein 20

F-box protein FBL2

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FBXL20 RGD RGD:621722
Felis catus FBXL20 VGNC VGNC:97433
Bos taurus FBXL20 VGNC VGNC:52776
Mus musculus FBXL20 MGD MGI:1919444
Canis familiaris FBXL20 VGNC VGNC:54947
Macaca mulatta FBXL20 VGNC VGNC:81407