1. Gene
  2. NDST2 - N-deacetylase and N-sulfotransferase 2 Gene

NDST2 - N-deacetylase and N-sulfotransferase 2 Gene

中文名称:N-脱乙酰酶和 N-磺基转移酶 2

种属: Homo sapiens

同用名: NST2; HSST2; N-HSST 2

基因 ID: 8509 | 基因类型: protein coding

关于 NDST2

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,801,916-73,811,820 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 13.3), bone marrow (RPKM 9.9) and 25 other tissues.

功能概要

该基因编码磺基转移酶 1 蛋白的 N-脱乙酰酶/N-磺基转移酶亚家族成员。编码的酶在处理氨基葡萄糖和肝素聚合物方面具有双重功能,包括 N-脱乙酰化和 N-硫酸化。编码的蛋白质可以定位于高尔基体。[RefSeq 提供,2009 年 2 月]

This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin Polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]

NDST2 基因产物(2)

mRNA Protein Name
NM_001330107.2 NP_001317036.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 2
NM_003635.4 NP_003626.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 1

NDST2 蛋白结构

HSNSD

HSNSD: heparan sulfate-N-deacetylase (1 - 391)

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (481 - 729)

  • 0
  • 200
  • 400
  • 600
  • 760 a.a.
蛋白主名 其他名称

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NDST2 VGNC VGNC:106079
Mus musculus NDST2 MGD MGI:97040
Canis familiaris NDST2 VGNC VGNC:51905
Rattus norvegicus NDST2 RGD RGD:1304700