2. Gene
  3. CPZ - carboxypeptidase Z Gene

CPZ - carboxypeptidase Z Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羧肽酶 Z

种属: Homo sapiens

基因 ID: 8532 | 基因类型: protein coding

关于 CPZ

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:8,592,765-8,619,752 (from NCBI)

This gene has 9 transcripts (splice variants), 258 orthologues and 7 paralogues. Biased expression in ovary (RPKM 47.9), placenta (RPKM 26.8) and 8 other tissues.

功能概要

该基因编码金属羧肽酶家族的一个成员。该酶对具有碱性 C 末端残基的底物显示出羧肽酶活性。它在中性 pH 值下最活跃，并被金属羧肽酶的活性定点抑制剂抑制。编码区的可变剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays Carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CPZ 基因产物(3)

mRNA Protein Name
NM_001014447.3 NP_001014447.2 carboxypeptidase Z isoform 1 precursor
NM_001014448.3 NP_001014448.2 carboxypeptidase Z isoform 3
NM_003652.4 NP_003643.3 carboxypeptidase Z isoform 2 precursor

CPZ 蛋白结构

Fz

Fz: Fz domain (43 - 157)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (194 - 493)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (506 - 570)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 652 a.a.
蛋白主名 其他名称

carboxypeptidase Z

VEZT/CPZ fusion

关联疾病

疾病名称 别名
Locked-In Syndrome

Locked In Syndrome

Cerebromedullospinal Disconnection

Locked-In State

Quadriplegia
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V
Cataract 11, Multiple Types

Cataract, Posterior Polar, 4

Ctpp4

Cpp4

Cataract 11 Multiple Types

CTRCT11

Cataract 11, Syndromic, Autosomal Recessive

Cataract 11 With Microphthalmia And Neurodevelopmental Abnormalities

Posterior Polar Cataract 4

Posterior Polar Cataract, 4

Cataract Posterior Polar 4

Syndromic Cataract 11

Cataract, Type 11, Multiple Types
Schizoid Personality Disorder
Sexual Sadism

Sadism
Amusia

Receptive Amusia
Myasthenic Syndrome, Congenital, 1a, Slow-Channel

Congenital Myasthenic Syndrome 1a

Congenital Myasthenic Syndrome 2a

CMS1A

Cms Iia

Congenital Myasthenic Syndrome Type Iia

Cms2a

Myasthenic Syndrome, Congenital, Type Iia, Formerly

Cms2a, Formerly

Cms Iia, Formerly

Congenital Myasthenic Syndrome 1a, Slow-Channel

Congenital Myasthenic Syndrome 2a Slow-Channel

Congenital Myasthenic Syndrome Post-Synaptic Slow-Channel

Myasthenic Syndrome, Congenital, Slow-Channel

Sccms

Myasthenic Syndrome, Congenital, Type 1a, Slow-Channel

Myasthenic Syndrome, Congenital, Postsynaptic Slow-Channel

Myasthenic Syndromes, Congenital, Slow Channel
Paranoid Personality Disorder
Phonagnosia
Myasthenic Syndrome, Congenital, 16

Congenital Myasthenic Syndrome 16

CMS16

Myasthenic Syndrome, Congenital, Acetazolamide-Responsive

Congenital Myasthenic Syndrome Acetazolamide-Responsive

Congenital Myasthenic Syndrome Due To Mutation In Scn4a

Congenital Myasthenic Syndrome Scn4a-Related
Bestiality

Zoophilia
Alexithymia
Schizotypal Personality Disorder

Schizotypal Personality
Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder
Corneal Disease

Corneal Diseases

Corneal Disorders
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101435 Centpropazine Antagonist / 否
HY-RS03130 CPZ Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-N12823 Caprazene / 否
HY-RS16701 Cpz Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23135 Cpz Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CPZ RGD RGD:620496
Canis familiaris CPZ VGNC VGNC:39587
Mus musculus CPZ MGD MGI:88487
Macaca mulatta CPZ VGNC VGNC:71478
Felis catus CPZ VGNC VGNC:61153
Bos taurus CPZ VGNC VGNC:27683
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