2. Gene
  3. NPFF - neuropeptide FF-amide peptide precursor Gene

NPFF - neuropeptide FF-amide peptide precursor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经肽 FF-酰胺肽前体

种属: Homo sapiens

同用名: FMRFAL

基因 ID: 8620 | 基因类型: protein coding

关于 NPFF

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,506,688-53,507,484 (from NCBI)

This gene has 2 transcripts (splice variants) and 148 orthologues. Ubiquitous expression in skin (RPKM 3.8), spleen (RPKM 2.1) and 24 other tissues.

功能概要

该基因编码 FMRFamide 相关肽 (FARP) 神经肽家族的成员。编码的前原蛋白经过蛋白水解处理以生成多个酰胺化肽。这些肽可能在调节心率和血压以及调节吗啡诱导的抗伤害作用方面发挥作用。高血压患者表现出编码蛋白的表达降低。可变剪接导致多个转录本变体，其中至少一个编码一种经过蛋白水解处理的亚型。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

NPFF 基因产物(2)

mRNA Protein Name
NM_001320296.2 NP_001307225.1 pro-FMRFamide-related neuropeptide FF isoform 2
NM_003717.4 NP_003708.1 pro-FMRFamide-related neuropeptide FF isoform 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables neuropeptide activity IDA
IDA: 通过直接分析推断
11024015 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in neuropeptide signaling pathway IDA
IDA: 通过直接分析推断
11024015 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NPFF 蛋白结构

NPFF

NPFF: Neuropeptide FF (31 - 113)

  • 0
  • 100
  • 113 a.a.
蛋白主名 其他名称

pro-FMRFamide-related neuropeptide FF

关联疾病

疾病名称 别名
Migraine With Aura

Classic Migraine

Migraine With Typical Aura

Migraine Accompagnée

Complicated Migraine

Classical Migraine

Acute Migraine With Aura
Opiate Dependence

Opioid Dependence

Opioid Addiction

Opiate Addiction

Opioid Type Dependence

Opioid-Related Disorders

Opium Dependence

Narcotic Dependence

Intravenous Narcotism

Narcotism Nos

Oral Narcotism Nos
Postsurgical Hypothyroidism

Postoperative Hypothyroidism

Post-Surgical Hypothyroidism
Pain Agnosia

Analgesia
N Syndrome

NSX

Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia
Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Opioid Abuse

Opioid-Related Disorders
Hermansky-Pudlak Syndrome 3

HPS3

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Delta Storage Pool Disease

Hermansky-Pudlak Syndrome, Type 3

Platelet Storage Pool Deficiency

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107726 BIBP3226 TFA Antagonist 99.25% 否
HY-P1248 Neuropeptide FF 99.35% 否
HY-P1428 RFRP-1(human) Agonist 99.00% 否
HY-P1250 RFRP-3(human) Agonist 99.43% 否
HY-P1245 Neuropeptide SF (human) Activator 99.53% 否
HY-107726A BIBP3226 Antagonist / 否
HY-161405 NPFF1-R antagonist 1 Inhibitor 99.38% 否
HY-P10377 GUB03385 Agonist 97.75% 否
HY-P10380A palm11-PrRP31 TFA Agonist 99.44% 否
HY-154829A AC-099 hydrochloride Agonist 99.92% 否
HY-P10379 palm-PrRP31 Agonist / 否
HY-P10380 palm11-PrRP31 Agonist / 否
HY-P1245A Neuropeptide SF (human) acetate Activator / 否
HY-P1249 Neuropeptide SF(mouse,rat) Agonist / 否
HY-P1249A Neuropeptide SF(mouse,rat) TFA Agonist / 否
HY-P1250A RFRP-3(human) TFA Agonist / 否
HY-P1428A RFRP-1(human) TFA Agonist / 否
HY-P3843 Neuropeptide AF (cattle) Agonist / 否
HY-RS09480 NPFF Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-154829 AC-099 Agonist / 否
HY-161382 NPFF2-R ligand 1 Ligand / 否
HY-RS16912 Npff Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23354 Npff Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NPFF RGD RGD:62033
Mus musculus NPFF MGD MGI:1891708
Bos taurus NPFF VGNC VGNC:32198
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