2. Gene
  3. DIRAS3 - DIRAS family GTPase 3 Gene

DIRAS3 - DIRAS family GTPase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DIRAS 家族 GTPase 3

种属: Homo sapiens

同用名: ARHI; NOEY2

基因 ID: 9077 | 基因类型: protein coding

关于 DIRAS3

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:68,045,962-68,050,627 (from NCBI)

This gene has 4 transcripts (splice variants), 50 orthologues and 35 paralogues. Biased expression in ovary (RPKM 20.7), adrenal (RPKM 6.9) and 11 other tissues.

功能概要

该基因编码 Ras 超家族的一个成员。该基因是与生长抑制相关的父系等位基因的单等位基因表达的印迹基因。编码的蛋白质充当肿瘤抑制因子，其功能在许多卵巢癌和乳腺癌中被废除。这种蛋白质还可能通过调节自噬体起始复合物在某些癌细胞中发挥自噬作用。[RefSeq 提供，2015 年 11 月]

This gene encodes a member of the Ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role Autophagy in certain Cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]

DIRAS3 基因产物(1)

mRNA Protein Name
NM_004675.5 NP_004666.1 GTP-binding protein Di-Ras3 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21643014 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DIRAS3 蛋白结构

Ras

Ras: Ras family (39 - 197)

  • 0
  • 100
  • 200
  • 229 a.a.
蛋白主名 其他名称

GTP-binding protein Di-Ras3

DIRAS family, GTP-binding RAS-like 3

DIRAS3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DIRAS3 O95661 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
DIRAS3 O95661 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
DIRAS3 O95661 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
DIRAS3 O95661 STAT3 Homo sapiens P40763
Anti Bait CoIP
21643014
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DIRAS3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75500 ARHI Protein, Human (HEK293, Fc) O95661 (M1-K225) ≥ 85%, as determined by reducing SDS-PAGE.

关联疾病

疾病名称 别名
Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal

Tndm

Chromosome 6-Associated Transient Diabetes Mellitus

Dmtn

Diabetes Mellitus, 6q24-Related Transient Neonatal

Tndm1

Neonatal Diabetes Mellitus, Transient

Tndm -[Transient Neonatal Diabetes Mellitus]
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome

BWS

Exomphalos-Macroglossia-Gigantism Syndrome

Emg Syndrome

Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

Emg Abnormality

Wbs

Exomphalos Macroglossia Gigantism Syndrome

Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

Macroglossia Exomphalos Gigantism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03777 DIRAS3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DIRAS3 VGNC VGNC:28071
Macaca mulatta DIRAS3 VGNC VGNC:71827
Rattus norvegicus DIRAS3 RGD RGD:1565168
Others DIRAS3 NCBI
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