1. Gene
  2. VCY - variable charge Y-linked Gene

VCY - variable charge Y-linked Gene

中文名称:可变电荷 Y 联

种属: Homo sapiens

同用名: BPY1; VCY1; VCY1A

基因 ID: 9084 | 基因类型: protein coding

关于 VCY

Cytogenetic location: Yq11.221 Genomic coordinates (GRCh38): Y:13,985,772-13,986,473 (from NCBI)

This gene has 1 transcript (splice variant), 28 orthologues, 5 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 20.6).

功能概要

该基因编码的蛋白质是人类 VCX/Y 基因家族的成员。这个基因家族在 X 和 Y 染色体上都有多个成员,并且都只在雄性生殖细胞中表达。 VCX/Y 家族的成员具有高度的序列同一性,除了一个 30 bp 单元在 X 连锁成员中串联重复但在 Y 连锁成员中仅出现一次。 VCX/Y 基因编码功能未知的小而高电荷的蛋白质。该基因编码一种带正电荷的小蛋白质。假定的二分核定位信号的存在表明该基因编码核蛋白。基因组在一个回文区域内有两个相同的基因拷贝;该记录代表更多的着丝粒拷贝。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. [provided by RefSeq, Jul 2008]

VCY 基因产物(1)

mRNA Protein Name
NM_004679.4 NP_004670.1 testis-specific basic protein Y 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

testis-specific basic protein Y 1

basic charge, Y-linked 1

关联疾病

疾病名称 别名
Spermatogenic Failure, Y-Linked, 2

SPGFY2

Spermatogenic Failure, Nonobstructive, Y-Linked

Y-Linked Spermatogenic Failure 2

Azoospermia, Nonobstructive, Y-Linked

Oligozoospermia, Nonobstructive, Y-Linked

Oligospermia, Nonobstructive, Y-Linked

Spermatogenic Arrest, Y-Linked

Nonobstructive Y-Linked Spermatogenic Failure

Spermatogenic Failure Y-Linked 2

Azoospermia Non-Obstructive Y-Linked

Non-Obstructive Azoospermia And Infertility

Oligospermia Non-Obstructive Y-Linked

Oligozoospermia Non-Obstructive Y-Linked

Spermatogenic Arrest Y-Linked

Spermatogenic Failure Nonobstructive Y-Linked

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma