EPSTI1 - epithelial stromal interaction 1 Gene

中文名称：上皮间质相互作用 1

种属: Homo sapiens

同用名: BRESI1

基因 ID: 94240 | 基因类型: protein coding

关于 EPSTI1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:42,886,388-42,992,241 (from NCBI)

This gene has 10 transcripts (splice variants) and 164 orthologues. Broad expression in lymph node (RPKM 5.8), spleen (RPKM 5.8) and 23 other tissues.

功能概要

该基因编码的蛋白质已被证明在过度表达时会促进某些浸润性癌细胞的肿瘤侵袭和转移。该基因的表达已显示通过 Kruppel 样因子 8 蛋白与启动子序列的直接结合而上调。翻译的蛋白质与含有缬乐肽的蛋白质基因产物的氨基末端区域相互作用，导致核因子 kappa B 亚基 1 基因产物的核转位，并激活靶基因。已在一些乳腺癌和一些系统性红斑狼疮 (SLE) 患者中观察到该基因的过度表达。[RefSeq 提供，2016 年 9 月]

The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive Cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE). [provided by RefSeq, Sep 2016]

EPSTI1 基因产物(4)

mRNA	Protein	Name
NM_001002264.4	NP_001002264.1	epithelial-stromal interaction protein 1 isoform 1
NM_001330543.2	NP_001317472.1	epithelial-stromal interaction protein 1 isoform 3
NM_001331228.2	NP_001318157.1	epithelial-stromal interaction protein 1 isoform 4
NM_033255.5	NP_150280.1	epithelial-stromal interaction protein 1 isoform 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

epithelial-stromal interaction protein 1

epithelial stromal interaction 1 (breast)

EPSTI1 抗体

目录号	产品名	应用	反应物种
HY-P89541	EPSTI1 Antibody (YA8885)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

关联疾病

疾病名称

别名

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04458	EPSTI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	EPSTI1	VGNC	VGNC:102195
Mus musculus	EPSTI1	MGD	MGI:1915168
Bos taurus	EPSTI1	VGNC	VGNC:28557
Macaca mulatta	EPSTI1	VGNC	VGNC:72053
Rattus norvegicus	EPSTI1	RGD	RGD:1563207

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EPSTI1 - epithelial stromal interaction 1 Gene

关于 EPSTI1

功能概要

EPSTI1 基因产物(4)

EPSTI1 抗体

关联疾病

直系同源

热门区域

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EPSTI1 - epithelial stromal interaction 1 Gene

关于 EPSTI1

功能概要

EPSTI1 基因产物(4)

EPSTI1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z