2. Gene
  3. AREL1 - apoptosis resistant E3 ubiquitin protein ligase 1 Gene

AREL1 - apoptosis resistant E3 ubiquitin protein ligase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：抗凋亡 E3 泛素蛋白连接酶 1

种属: Homo sapiens

同用名: FIEL1; KIAA0317

基因 ID: 9870 | 基因类型: protein coding

关于 AREL1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:74,661,256-74,713,080 (from NCBI)

This gene has 18 transcripts (splice variants), 205 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 15.1), thyroid (RPKM 12.5) and 25 other tissues.

功能概要

启用泛素蛋白转移酶活性。参与细胞凋亡过程的负调控；蛋白质泛素化；和泛素依赖性蛋白质分解代谢过程。位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

AREL1 基因产物(2)

mRNA Protein Name
NM_001039479.2 NP_001034568.1 apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1
NM_001411046.1 NP_001397975.1 apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23479728 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
25752577 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
23479728 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
23479728 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
25752577 GOA
involved in protein K33-linked ubiquitination IDA
IDA: 通过直接分析推断
25752577 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
31578312 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
23479728 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
23479728 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AREL1 蛋白结构

Filamin

Filamin: Filamin/ABP280 repeat (54 - 154)

HECT

HECT: HECT-domain (ubiquitin-transferase) (513 - 822)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
蛋白主名 其他名称

apoptosis-resistant E3 ubiquitin protein ligase 1

apoptosis-resistant HECT-type E3 ubiquitin transferase 1

关联疾病

疾病名称 别名
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Colorectal Cancer, Hereditary Nonpolyposis, Type 7

HNPCC7

Hereditary Nonpolyposis Colorectal Cancer Type 7

Hereditary Non-Polyposis Colorectal Cancer 7

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 7
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00893 AREL1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus AREL1 MGD MGI:1915747
Canis familiaris AREL1 VGNC VGNC:38029
Felis catus AREL1 VGNC VGNC:59865
Rattus norvegicus AREL1 RGD RGD:1307597
Bos taurus AREL1 VGNC VGNC:26058
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