DMTF1 - cyclin D binding myb like transcription factor 1 Gene

中文名称：细胞周期蛋白 D 结合 myb 样转录因子 1

种属: Homo sapiens

同用名: DMP1; DMTF; MRUL; hDMP1

基因 ID: 9988 | 基因类型: protein coding

关于 DMTF1

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:87,152,453-87,196,325 (from NCBI)

This gene has 38 transcripts (splice variants), 209 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 18.8), lymph node (RPKM 11.3) and 25 other tissues.

功能概要

该基因编码的转录因子包含一个细胞周期蛋白 D 结合结构域、三个中央 Myb 样重复序列以及位于 N 和 C 末端的两个侧翼酸性反式激活结构域。编码的蛋白质由致癌 Ras 信号通路诱导，并通过激活 ARF 的转录和 ARF-p53 通路来抑制细胞生长或诱导细胞凋亡，从而发挥肿瘤抑制因子的作用。它还激活氨肽酶 N 的转录，并可能在造血细胞分化中发挥作用。该蛋白的转录活性受 D-细胞周期蛋白结合的调节。该基因在大约 40% 的人类非小细胞肺癌中半合子缺失，是非小细胞肺癌的潜在预后和基因治疗靶点。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 12 月]

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce Apoptosis. It also activates the transcription of Aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung Cancer and is a potential prognostic and gene-therapy target for non-small-cell lung Cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

DMTF1 基因产物(3)

mRNA	Protein	Name
NM_001142326.2	NP_001135798.1	cyclin-D-binding Myb-like transcription factor 1 isoform b
NM_001142327.2	NP_001135799.1	cyclin-D-binding Myb-like transcription factor 1 isoform a
NM_021145.4	NP_066968.3	cyclin-D-binding Myb-like transcription factor 1 isoform a

DMTF1 蛋白结构

Myb_DNA-binding

0
200
400
600
760 a.a.

蛋白主名

其他名称

cyclin-D-binding Myb-like transcription factor 1

cyclin D-binding Myb-like protein

关联疾病

疾病名称

别名

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03833	DMTF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	DMTF1	VGNC	VGNC:28116
Mus musculus	DMTF1	MGD	MGI:1344415
Felis catus	DMTF1	VGNC	VGNC:61532
Canis familiaris	DMTF1	VGNC	VGNC:40004
Macaca mulatta	DMTF1	VGNC	VGNC:71837
Rattus norvegicus	DMTF1	RGD	RGD:70966

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DMTF1 - cyclin D binding myb like transcription factor 1 Gene

关于 DMTF1

功能概要

DMTF1 基因产物(3)

DMTF1 蛋白结构

关联疾病

直系同源

热门区域

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DMTF1 - cyclin D binding myb like transcription factor 1 Gene

关于 DMTF1

功能概要

DMTF1 基因产物(3)

DMTF1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z