2. Immunology/Inflammation
  3. CTLA-4
  4. GIGA-564

GIGA-564 是一种全人源抗 CTLA4 IgG1 单克隆抗体，Kd 为 9.8 nM。GIGA-564 可结合 CTLA-4 的独特表位，介导 FcR 依赖性信号通路，耗竭肿瘤内高表达 CTLA-4 的调节性 T 细胞，并抑制外周调节性 T 细胞增殖。GIGA-564 在 小鼠模型中展现出抗肿瘤活性。GIGA-564 可用于肿瘤的研究。

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GIGA-564

GIGA-564 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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Customer Review

GIGA-564 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GIGA-564 is a fully human anti-CTLA4 IgG1 monoclonal antibody with a Kd of 9.8 nM. GIGA-564 binds to a unique epitope of CTLA-4, mediates FcR-dependent signaling pathways, depletes CTLA-4-highly-expressing regulatory T cells within tumors, and inhibits the proliferation of peripheral regulatory T cells. GIGA-564 exhibits anti-tumor activity in mouse models. GIGA-564 can be used for tumor research[1].

反应种属

Human
体外研究
(In Vitro)

GIGA-564 (0.001-100 μg/mL) 在 ELISA 实验中阻断 CTLA-4 与 CD80、CD86 结合的活性极低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GIGA-564 相关抗体:
体内研究
(In Vivo)

GIGA-564 (5 mg/kg; i.p.; once every 3 days; 3 doses) 在携带有 MC38 肿瘤的 hCTLA-4 KI 小鼠中诱导的外周 Treg 增殖水平低于 Ipilimumab (HY-P9901)[1]。
GIGA-564 (0.3 mg/kg; i.p.; once every 3 days; 3 doses) 在携带有 MC38 肿瘤的 hCTLA-4 KI 小鼠中展现出优异的抗肿瘤活性[1]。
GIGA-564 (30 mg/kg; i.p.; once every 3 days; 9 doses) 在 hCTLA-4 基因敲入 (KI) 和 hCTLA-4/hPD-1 双基因敲入 (KI) 小鼠中诱导的毒性低于 Ipilimumab (HY-P9901)，表现为肝酶水平更低、结肠炎减轻，且在测试剂量下无皮肤病变[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hCTLA-4 KI (implanted with MC38 tumor cells)[1]
Dosage: 0.3 mg/kg
Administration: i.p.; once every 3 days; 3 doses
Result: Resulted in significantly smaller tumor volumes, with a significantly lower mean tumor volume at day 25 compared to ipilimumab and isotype control.
Improved survival probability.
基因 ID

1493  [NCBI]

Accession
靶点

CTLA4
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GIGA-564 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GIGA-564GIGA564GIGA 564CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152murine modelsregulatory T cellshCTLA-4/hPD-1 double KI miceperipheral regulatory T cell proliferationmc38 tumorsCD80hCTLA-4 KI miceInhibitorinhibitorinhibit

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产品名称：
GIGA-564
目录号：
HY-P991958
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