2. Anti-infection
  3. SARS-CoV
  4. GK730

GK730 是一种强效且具有选择性的 SARS-CoV 2 型主蛋白酶 (SARS-CoV-2 main protease) 抑制剂，其 IC50 值为 5.75 nM。GK730 不会抑制组织蛋白酶 B，但对组织蛋白酶 L 的抑制作用较弱 (IC50 值为 11 μM)。GK730 能够同时阻断病毒的复制以及奥密克戎等变异株进入细胞的途径。GK730 对 Vero E6 细胞中野生型 SARS-CoV-2 毒株的 EC50 值为 5.70 μM，且 CC50 值大于 100μM。GK730 可用于新型冠状病毒肺炎 (COVID-19) 的研究。

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GK730

GK730 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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GK730 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GK730 is a potent and selective SARS-CoV-2 main protease inhibitor with an IC50 of 5.75 nM. GK730 does not inhibit cathepsin B, while exhibits weak inhibition of cathepsin L (IC50 = 11 μM). GK730 can simultaneously block the replication of the virus and the entry pathways for variants such as Omicron into cells. GK730 demonstrates an EC50 value of 5.70 μM against a wild-type SARS-CoV-2 strain in Vero E6 cells and CC50 value greater than 100 μM. GK730 can be used for the research of COVID-19[1].

分子量

643.75

Formula

C31H41N5O8S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GK730 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GK730GK 730GK-730SARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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