2. Anti-infection
  3. Bacterial
  4. Glenthmycin E

Glenthmycin E 是一种被发现存在于澳大利亚绵羊牧场来源 Streptomyces sp. CMB-PB041 中的抗菌 (antibacterial) 剂。Glenthmycin E 可抑制多种细菌的生长，且对包括真菌和人类癌细胞在内的真核细胞无检测到的细胞毒性。Glenthmycin E 可用于细菌感染的研究。

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Glenthmycin E

Glenthmycin E Chemical Structure

CAS No. : 3040055-84-0

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Other Forms of Glenthmycin E:

Glenthmycin E 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glenthmycin E is an antibacterial agent found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin E inhibits growth of multiple bacterial and exhibits no detectable cytotoxicity to eukaryotic cells including fungal and human carcinoma cells. Glenthmycin E can be used for the research of bacterial infections[1].

体外研究
(In Vitro)

Glenthmycin E (0.01-30 μM; 16-24 h) 可抑制金黄色葡萄球菌 ATCC 25923 (IC50 4.9 μM)、粪肠球菌 (IC50 6.2 μM)、耐甲氧西林金黄色葡萄球菌 ATCC 43300 (IC50 3.9 μM)、耐甲氧西林金黄色葡萄球菌 ATCC 33591 (IC50 2.3 μM) 以及耐万古霉素肠球菌 (IC50 3.2 μM) 的生长[1]。
Glenthmycin E (48 h) 对人癌细胞 SW620 或 NCI-H460 无显著细胞毒性 (IC50 >30 μM)，在最高 30 μM 的浓度下也不会抑制白假丝酵母菌 (Candida albicans)、大肠埃希菌 (Escherichia coli)、牛分枝杆菌 (Mycobacterium bovis) BCG 或结核分枝杆菌 (Mycobacterium tuberculosis) H37Ra 的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glenthmycin E 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human colorectal carcinoma (SW620), human lung carcinoma (NCI-H460) cells
Concentration: 10 nM-30 μM
Incubation Time: 48 h
Result: Exhibited no significant cytotoxicity against SW620 or NCI-H460 cells (IC50 >30 μM).
分子量

889.03

Formula

C50H64O14
CAS 号
结构分类
初始来源

Streptomyces sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glenthmycin E 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glenthmycin E3040055-84-0BacterialCandida albicansmethicillin-resistant S. aureus ATCC 43300SW620methicillin-resistant S. aureus ATCC 33591Staphylococcus aureus ATCC 25923NCI-H460methicillin-resistant Staphylococcus aureusEnterococcus faecalisStreptomyces sp. CMB-PB041vancomycin-resistant EnterococciInhibitorinhibitorinhibit

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