2. Immunology/Inflammation Anti-infection
  3. CD1 IFNAR Interleukin Related Bacterial Influenza Virus
  4. Glycolipid C34

Glycolipid C34，一种 α-GalCer (HY-102022) 类似物，是一种 CD1d 结合型糖脂类抗感染剂。Glycolipid C34 介导恒定自然杀伤 T 细胞活化，并促进 IFN-γ 和 IL-4 的分泌。Glycolipid C34 可在小鼠模型中促进细菌感染的清除，并增强针对病毒感染的保护性免疫。Glycolipid C34 可用于细菌感染、病毒感染的相关研究。

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Glycolipid C34

Glycolipid C34 Chemical Structure

CAS No. : 1204401-08-0

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Glycolipid C34 相关抗体

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glycolipid C34, α-GalCer (HY-102022) analog, is a CD1d-binding glycolipid antinfection agent. Glycolipid C34 mediates invariant natural killer T cell activation and increases the secretion of IFN-γ and IL-4. Glycolipid C34 promotes clearance of bacterial infections in murine models and enhances protective immunity against viral infections. Glycolipid C34 can be used for the research of bacterial infection, viral infection[1].

IC50 & Target[1]

CD1d

 

IL-4

 

体外研究
(In Vitro)

Glycolipid C34 可通过结合 CD1d 介导恒定自然杀伤 T 细胞活化，并促进 IFN-γ 和 IL-4 的分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glycolipid C34 相关抗体:
体内研究
(In Vivo)

Glycolipid C34 (50 μg/kg；腹腔注射；单剂量；感染后 3 小时) 可显著降低 Sphingomonas capsulata 感染的 C57BL/6 小鼠肝脏细菌载量[1]。
Glycolipid C34 (150 μg/kg；腹腔注射；单次给药；感染后 3 小时) 可显著降低 S. aureus Xen29 大腿感染 BALB/c 小鼠的细菌载量[1]。
Glycolipid C34 (150 μg/kg；腹腔注射；单剂量；感染后 0-6 h) 立即给药可显著降低 S. aureus Xen29 大腿感染的 BALB/c 小鼠的细菌载量，而延迟给药 (感染后 6 小时) 的疗效会下降[1]。
Glycolipid C34 (1 μg；腹腔注射；2 次给药；攻毒前 1 天和攻毒后 1 天) 可提升感染 JEV 和 WSN 的 C57BL/6 小鼠的存活率，且其保护作用依赖于完整的固有免疫和适应性免疫组分[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 6 to 8 weeks old; Sphingomonas capsulata infection model)[1]
Dosage: 50 μg/kg
Administration: i.p.; single dose; 3 hours post-infection
Result: Significantly reduced liver bacterial CFU counts compared to vehicle control (P < 0.01), with mean CFU counts lower than those seen with α-GalCer treatment.
Animal Model: BALB/c (female; Staphylococcus aureus Xen29 deep thigh wound infection model)[1]
Dosage: 150 μg/kg
Administration: i.p.; single dose; 0, 3, 6 hours post-infection
Result: Significantly reduced relative luminescence units (a marker of bacterial burden) compared to vehicle control (P < 0.05), with a greater degree of bacterial clearance than seen with α-GalCer treatment.
Animal Model: C57BL/6 (7 weeks old; Japanese encephalitis virus RP-9 strain and influenza virus WSN infection model)[1]
Dosage: 1 μg
Administration: i.p.; two doses; 1 day pre-challenge and 1 day post-challenge
Result: Significantly prolonged survival compared to vehicle control.
分子量

834.11

Formula

C47H76FNO10
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glycolipid C34 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycolipid C341204401-08-0Glycolipid C 34Glycolipid C-34CD1IFNARInterleukin RelatedBacterialInfluenza VirusInterferon-α/β receptorInterferon-alpha/beta receptor ILStat-1Sphingomonas capsulatamurine modelsJapanese encephalitis virusCD1dCD8α chainC57BL/6 miceT-helper-cell 1 cytokine responseimmunoglobulin μ chaininvariant natural killer T cellInhibitorinhibitorinhibit

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