2. Anti-infection
  3. Bacterial
  4. GN-2 peptoid

GN-2 peptoid 是一种 9 聚体阳离子两亲性类肽和杀菌剂，具有广谱抗菌活性。GN-2 peptoid 以浓度依赖的方式对大肠杆菌 (Escherichia coli) 发挥杀菌作用。GN-2 peptoid 对革兰氏阳性菌金黄色葡萄球菌 (Staphylococcus aureus) 以及革兰氏阴性菌大肠杆菌 (Escherichia coli)、铜绿假单胞菌 (Pseudomonas aeruginosa) 菌株均具有抗菌活性。GN-2 peptoid 对人红细胞和 HeLa 细胞的毒性较低。GN-2 peptoid 在含 50% 人血浆的环境中仍可维持抗菌活性。GN-2 peptoid 可用于细菌感染的相关研究。

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Custom Peptide Synthesis

GN-2 peptoid

GN-2 peptoid Chemical Structure

CAS No. : 1805781-73-0

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GN-2 peptoid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections[1].

体外研究
(In Vitro)

GN-2 peptoid 对金黄色葡萄球菌（ATCC 29213）和铜绿假单胞菌（PAO1）的 MIC 均为 3.13 μg/mL，对大肠杆菌的 MIC 为 6.25 μg/mL，具有中等抗菌活性（SR = 4–32），无溶血性（>128 μg/mL）[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GN-2 peptoid 相关抗体:

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[1]

Cell Line: Hela WT cell
Concentration: 47 μg/mL
Incubation Time: /
Result: Showed cytotoxicity against human cells.
分子量

1443.82

Formula

C78H110N18O9
CAS 号
Sequence

{Nlys}-{Ntrp}-{Nlys}-{Nlys}-{Ntrp}-{Ntrp}-{Nlys}-{Ntrp}-{Nile}-NH2
Sequence Shortening

{Nlys}-{Ntrp}-{Nlys}-{Nlys}-{Ntrp}-{Ntrp}-{Nlys}-{Ntrp}-{Nile}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GN-2 peptoid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GN-2 peptoid1805781-73-0BacterialStaphylococcus aureusHeLa cellsGram-negativeEscherichia colimammalian cellsPseudomonas aeruginosahuman red blood cellshuman blood plasmaGram-positivebacterial infectionsInhibitorinhibitorinhibit

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