2. GPCR/G Protein
  3. GnRH Receptor
  4. GnRH-R antagonist-3

GnRH-R antagonist-3 (Compound 37) 是一种促性腺激素释放激素受体 (GnRH-R) 拮抗剂，对大鼠和人 GnRH-R 的 IC50 分别为 94 nM 和 275 nM。GnRH-R antagonist-3 可用于激素依赖性疾病，如子宫内膜异位症、乳腺癌和前列腺癌研究。

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GnRH-R antagonist-3

GnRH-R antagonist-3 Chemical Structure

CAS No. : 666852-12-6

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GnRH-R antagonist-3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GnRH-R antagonist-3 (Compound 37) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC50s of 94 and 275 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-3 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
275 nM
Compound: 37
Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cells
Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cells
[PMID: 17937987]
Pituitary gland cell IC50
743 nM
Compound: 37
Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pituitary cells assessed as inhibition of GnRH stimulated LH release after 24 hrs
Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pituitary cells assessed as inhibition of GnRH stimulated LH release after 24 hrs
[PMID: 17937987]
分子量

645.90

Formula

C37H51N5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GnRH-R antagonist-3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GnRH-R antagonist-3666852-12-6GnRH ReceptorGonadotropin releasing hormone receptorGNRHRGnRH-REndometriosisBreast cancerProstate cancerInhibitorinhibitorinhibit

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