2. Neuronal Signaling
  3. Tau Protein
  4. Gosuranemab (powder)

Gosuranemab (powder)  (Synonyms: BMS-986168 (powder); IPN007 (powder); BIIB092 (powder))

目录号: HY-P99648A
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技术支持

Gosuranemab (BMS-986168; IPN007; BIIB092) (powder) 是一种人源化 IgG4 抗 tau 单克隆抗体。Gosuranemab (powder) 可中和细胞外 tau 蛋白，抑制病理性 tau 蛋白的扩散与聚集。Gosuranemab (powder) 可用于进行性核上性麻痹和早期阿尔茨海默病的研究。

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Gosuranemab (powder)

Gosuranemab (powder) Chemical Structure

CAS No. : 1788032-39-2

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Gosuranemab (powder) 的其他形式现货产品:

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Gosuranemab (powder) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gosuranemab (BMS-986168; IPN007; BIIB092) (powder) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab (powder) neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab (powder) can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease[1][2].

体外研究
(In Vitro)

Gosuranemab (powder) 对单体和聚集态 tau 蛋白表现出高结合亲和力，并能从阿尔茨海默病 (AD) 脑裂解物中清除具有播种活性的 tau 蛋白[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gosuranemab (powder) 相关抗体:
体内研究
(In Vivo)

Gosuranemab (powder) (抗鼠源版本 IPN002；每周给药；持续 8 周) 可降低 rTg4510 tau 病转基因小鼠脑脊液和间质液中的游离 tau 蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rTg4510[1]
Dosage: murine version IPN002
Administration: weekly; 8 weeks
Result: Reduced levels of unbound tau in cerebrospinal fluid (CSF) and interstitial fluid (ISF) at 57 days post-treatment initiation.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gosuranemab (powder) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gosuranemab (powder)1788032-39-2BMS-986168 (powder) IPN007 (powder) BIIB092 (powder)Tau ProteinAD brain homogenatestotal tauextracellular N-terminal taurTg4510 tauopathy transgenic micephosphorylated tau181Alzheimer’s diseaseprogressive supranuclear palsytau PET SUVRblood-brain barriercerebrospinal fluidInhibitorinhibitorinhibit

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