2. GPR84 antagonist 11

GPR84 antagonist 11 是一种高选择性的 GPR84 拮抗剂，其人源 pA2 为 8.41、pKi 为 8.16。GPR84 antagonist 11 可竞争性抑制激动剂与 GPR84 正构位点的结合，且具有改善的类药属性，但其代谢稳定性仍有待优化。GPR84 antagonist 11 可用于自身免疫性疾病、纤维化疾病的研究。

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GPR84 antagonist 11

GPR84 antagonist 11 Chemical Structure

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GPR84 antagonist 11 相关抗体

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生物活性

GPR84 antagonist 11 is a highly selective GPR84 antagonist, with a human pA2 of 8.41 and a pKi of 8.16. GPR84 antagonist 11 competitively inhibits the binding of agonists to the orthosteric site of GPR84 and has improved druglike properties, though its metabolic stability still requires optimization. GPR84 antagonist 11 can be used in the research of autoimmune diseases and fibrotic diseases[1].

体外研究
(In Vitro)

GPR84 antagonist 11 (Compound 42E2) 是小鼠 GPR84 的中等强度竞争性正构拮抗剂，其 pA2 为 6.4[1]。
GPR84 antagonist 11 对 FFAR1、FFAR2、FFAR3 或 FFAR4 均无显著活性，显示出对 GPR84 的显著选择性[1]。
GPR84 antagonist 11 具有良好的溶解度、logD 和血浆蛋白结合特性，但在小鼠肝微粒体中表现出较差的代谢稳定性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GPR84 antagonist 11 相关抗体:
分子量

356.46

Formula

C21H28N2O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GPR84 antagonist 11 相关分类

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Keywords:

GPR84 antagonist 11FFAR3FFAR2FFAR1autoimmune disordersFFAR4fibrotic disordersmouse GPR84 orthologmouse liver microsomesGPR84[35S]GTPγS binding assaysInhibitorinhibitorinhibit

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