2. Membrane Transporter/Ion Channel Anti-infection
  3. Potassium Channel Parasite
  4. GSK369796

GSK369796 是一种经济有效的抗疟药，可抑制 hERG 钾离子通道 (hERG potassium ion channel) 复极化，IC50 值为 7.5 μM。

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GSK369796

GSK369796 Chemical Structure

CAS No. : 459133-38-1

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GSK369796 的其他形式现货产品:

Other Forms of GSK369796:

GSK369796 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK369796 is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BHK-21 CC50
98.01 μM
Compound: 42; GSK369796
Cytotoxicity against BHK21 cells after 24 to 48 hrs by CCK8 assay
Cytotoxicity against BHK21 cells after 24 to 48 hrs by CCK8 assay
[PMID: 31549836]
Vero EC50
2.57 μM
Compound: 42; GSK369796
Antiviral activity against Zika virus MR766 infected in African green monkey Vero cells by plaque assay
Antiviral activity against Zika virus MR766 infected in African green monkey Vero cells by plaque assay
[PMID: 31549836]
Vero C1008 EC50
1.2 μM
Compound: N-tert-Butylisoquine
Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs
Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs
10.1101/2020.04.16.044016
分子量

355.86

Formula

C20H22ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK369796 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK369796459133-38-1GSK 369796GSK-369796Potassium ChannelParasiteKcsAantimalarialhERGInhibitorinhibitorinhibit

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目录号：
HY-12082
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