2. PROTAC Apoptosis
  3. Molecular Glues Apoptosis
  4. GSPT1 degrader-17

GSPT1 degrader-17 (Compound 9q) 是一种强效且选择性的基于 cereblon 的分子胶降解剂，靶向 G1 至 S 期转换 1 (GSPT1)。GSPT1 degrader-17 在 U937 细胞中降解 GSPT1，其 DC50 值为 35 nM， Dmax 值为 81.65%。GSPT1 degrader-17 对 U937、MOLT-4 和 MV4-11 细胞具有强烈的抑制作用，其 IC50 值为 0.019、0.006 和 0.027 μM。GSPT1 degrader-17 可诱导凋亡 (apoptosis) 和 G0/G1 期阻滞。GSPT1 degrader-17 可用于癌症研究，如急性髓系白血病。

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GSPT1 degrader-17

GSPT1 degrader-17 Chemical Structure

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GSPT1 degrader-17 相关抗体

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生物活性

GSPT1 degrader-17 (Compound 9q) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-17 degrades GSPT1 in U937 cells with a DC50 of 35 nM and Dmax of 81.65%. GSPT1 degrader-17 has a strong inhibitory effect on U937, MOLT-4 and MV4-11 cells with IC50 values of 0.019, 0.006 and 0.027 μM. GSPT1 degrader-17 can induce cells apoptosis and G0/G1 phase arrest. GSPT1 degrader-17 can be used for the research of cancer, such as acute myeloid leukemia[1].

分子量

527.01

Formula

C27H31ClN4O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSPT1 degrader-17 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

GSPT1 degrader-17Molecular GluesApoptosisGSPT1U937MOLT-4MV4-11apoptosisG0G1acute myeloid leukemiaInhibitorinhibitorinhibit

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