2. GPCR/G Protein
  3. Leukotriene Receptor
  4. H-Ala-pNA

H-Ala-pNA 是一种 L-氨基酸对硝基苯胺 (pNA) 衍生物，是白三烯 A4 水解酶 (leukotriene A4 hydrolase) 的特异性底物。H-Ala-pNA 的 D 型对映体对白三烯 A4 水解酶无活性。H-Ala-pNA 可被白三烯 A4 水解酶催化水解，通过分光光度法在 405 nm 下监测反应生成的对硝基苯胺，从而实现对酶活性的定量检测。H-Ala-pNA 已被用于评估针对白三烯 A4 水解酶的酰胺酶活性的抑制剂效能。

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H-Ala-pNA

H-Ala-pNA Chemical Structure

CAS No. : 1668-13-9

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规格 是否有货
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Other Forms of H-Ala-pNA:

H-Ala-pNA 相关抗体

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

H-Ala-pNA is an L-amino acid p-nitroaniline (pNA) derivative and a specific substrate for leukotriene A4 hydrolase. The D-enantiomer of H-Ala-pNA shows no activity toward leukotriene A4 hydrolase. H-Ala-pNA can be catalytically hydrolyzed by leukotriene A4 hydrolase, and the p-nitroaniline produced during the reaction is monitored spectrophotometrically at 405 nm to enable quantitative detection of enzyme activity. H-Ala-pNA is used to evaluate the potency of inhibitors targeting the amidase activity of leukotriene A4 hydrolase[1].

体外研究
(In Vitro)

H-Ala-pNA (1.5 mM) 可被纯化的人白细胞白三烯 A4 水解酶水解，其 Km 为 500 μM，kcat 为 6.0×10-1 s-1，Vmax 为 530 nmol/min per mg，kcat/Km 为 1.2×103 M-1s-1[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

H-Ala-pNA 相关抗体:
分子量

209.20

Formula

C9H11N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

H-Ala-pNA 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Ala-pNA1668-13-9Leukotriene Receptorp-nitroanilineaminopeptidase activityhuman leukocyteleukotriene A4 hydrolaseamidase activityL-amino acid p-nitroanilideInhibitorinhibitorinhibit

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