2. GPCR/G Protein
  3. GLP Receptor
  4. H-Trp-Tyr-OH

H-Trp-Tyr-OH 是一种口服有效的色氨酸-酪氨酸二肽，具体血脑屏障穿透性。H-Trp-Tyr-OH 可通过刺激肠内分泌细胞分泌胰高血糖素样肽 GLP-1 发挥生理调节作用。在 tau 蛋白病小鼠模型中，H-Trp-Tyr-OH 能抑制 tau 蛋白磷酸化、降低神经原纤维缠结水平，同时增加多巴胺周转率、上调突触素表达、提高盲肠短链脂肪酸水平，进而改善行为缺陷并延长寿命。H-Trp-Tyr-OH 可用于糖耐量减低及 tau 蛋白病的相关研究。

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Custom Peptide Synthesis

H-Trp-Tyr-OH

H-Trp-Tyr-OH Chemical Structure

CAS No. : 19653-76-0

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规格 价格 是否有货 数量
5 mg ￥585
In-stock
10 mg ￥900
In-stock
25 mg ￥1800
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

H-Trp-Tyr-OH 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

H-Trp-Tyr-OH is an orally active tryptophan-tyrosine dipeptide with specific blood-brain barrier permeability. H-Trp-Tyr-OH exerts physiological regulatory effects by stimulating enteroendocrine cells to secrete glucagon-like peptide GLP-1. In mouse models of tauopathies, H-Trp-Tyr-OH inhibits tau phosphorylation, reduces the level of neurofibrillary tangles, increases dopamine turnover, upregulates synapsin expression, and elevates cecal short-chain fatty acid levels, thereby improving behavioral deficits and extending lifespan. H-Trp-Tyr-OH can be used in research related to impaired glucose tolerance and tauopathies[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDCK IC50
0.08 mM
Compound: 69
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
[PMID: 16759105]
体外研究
(In Vitro)

H-Trp-Tyr-OH (1-5 mg/mL; 60 min) 可强效刺激 GLUTag 细胞分泌 GLP-1，在 5 mg/mL 时活性最高 (诱导的 GLP-1 水平较空白对照高约 6 倍)，且对 GLUTag 细胞无细胞毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

H-Trp-Tyr-OH 相关抗体:

ELISA Assay[2]

Cell Line: murine enteroendocrine GLUTag cells
Concentration: 1 mg/mL; 2 mg/mL; 5 mg/mL; 1.85 mg/mL
Incubation Time: 60 min
Result: Induced a GLP-1 secretion level ~6-fold relative to blank control at 5 mg/mL.
Induced a GLP-1 level ~1-fold relative to blank control at 1 mg/mL.
Induced a GLP-1 level ~2-fold relative to blank control at 2 mg/mL.
Induced a GLP-1 level ~1.2-fold relative to blank control at 1.85 mg/mL.
Remained at baseline LDH release levels, showing no cytotoxicity.
体内研究
(In Vivo)

H-Trp-Tyr-OH (0.05% w/w；口服；持续膳食摄入) 可改善 PS19 tauopathy 小鼠的 tau 病变相关行为缺陷，提高多巴胺周转率和突触标志物水平，减少 tau 蛋白磷酸化，提升盲肠短链脂肪酸含量，并显著提高其存活率[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B6;C3-Tg mice (Prnp-MAPT*P301S)PS19Vle/J (PS19 transgenic; male and female, 2.5 months old, tauopathy model); wild-type littermates (male and female, 2.5 months old)[3]
Dosage: 0.05% w/w
Administration: p.o.; continuous dietary intake; 6.5 months (male); until 53 weeks of age (female)
Result: Reduced total distance traveled in the open field test at 5 and 7 months of age, normalizing locomotor hyperactivity.
Increased the number of NeuN-positive cells in the entorhinal cortex and elevated cortical synaptophysin levels in male mice.
Increased dopamine turnover (DOPAC/dopamine ratio and (DOPAC + HVA)/dopamine ratio) in the frontal cortex of male mice.
Reduced hippocampal pTau levels (113.1 vs control 162.2) and cortical pTau/tTau ratio (0.02 vs control 0.04) in male mice; reduced pTau-positive region in the spinal cord.
Achieved a 67% survival ratio at 53 weeks of age in female mice, significantly higher than control's 38%.
Increased cecal acetic acid and total short-chain fatty acid levels in male mice.
分子量

367.40

Formula

C20H21N3O4
CAS 号
性状

固体

颜色

White to off-white

Sequence

Trp-Tyr
Sequence Shortening

WY
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 25 mg/mL (68.05 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7218 mL 13.6091 mL 27.2183 mL
5 mM 0.5444 mL 2.7218 mL 5.4437 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

H-Trp-Tyr-OH 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7218 mL 13.6091 mL 27.2183 mL 68.0457 mL
5 mM 0.5444 mL 2.7218 mL 5.4437 mL 13.6091 mL
10 mM 0.2722 mL 1.3609 mL 2.7218 mL 6.8046 mL
15 mM 0.1815 mL 0.9073 mL 1.8146 mL 4.5364 mL
20 mM 0.1361 mL 0.6805 mL 1.3609 mL 3.4023 mL
25 mM 0.1089 mL 0.5444 mL 1.0887 mL 2.7218 mL
30 mM 0.0907 mL 0.4536 mL 0.9073 mL 2.2682 mL
40 mM 0.0680 mL 0.3402 mL 0.6805 mL 1.7011 mL
50 mM 0.0544 mL 0.2722 mL 0.5444 mL 1.3609 mL
60 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1341 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Trp-Tyr-OH19653-76-0GLP Receptorshort-chain fatty acidtauopathy mouse modelsenteroendocrine cellsneurofibrillary tangledopamine turnoverglucagon-like peptide-1GLUTag cellsPS19 tauopathy micesynaptophysintau phosphorylationInhibitorinhibitorinhibit

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