2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. HC-067047 hydrochloride

HC-067047 hydrochloride 是一种有效的选择性 TRPV4 拮抗剂，通过人，大鼠和小鼠 TRPV4 同源物可逆性的抑制电流，IC50 值分别为 48 nM，133 nM 和 17 nM。

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CAS No. : 1481646-76-7

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HC-067047 hydrochloride 的其他形式现货产品:

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Other Forms of HC-067047 hydrochloride:

HC-067047 hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 39 篇科研文献

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Cell Imaging/Staining
Bio/Physico-chemical Assay
WB
In Vivo Efficacy Study

    HC-067047 hydrochloride purchased from MCE. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388.  [Abstract]

    HC067047 (100 nM, transient administration) blocked both GSK1016790A (80 nM,transient administration) -evoked inward and outward transmembrane currents in HUVEC cells.

    HC-067047 hydrochloride purchased from MCE. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388.  [Abstract]

    HC067047 (1 µM, 2 h) decreased cell height and increased cell body area in HUVEC cells.

    HC-067047 hydrochloride purchased from MCE. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388.  [Abstract]

    HC067047 (1 µM, 2 h) compromised mitochondrial function, including a reduction in membrane potential, in HUVEC cells.

    HC-067047 hydrochloride purchased from MCE. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388.  [Abstract]

    HC067047 (1 µM, 2 h) increased basal respiration, maximal respiration, ATP production, and spare capacity in HUVEC cells.

    HC-067047 hydrochloride purchased from MCE. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388.  [Abstract]

    HC067047 (1 µM, 2 h) decreased TRPV4, NLRP3, ASC, and p20 caspase-1 protein expression in HUVECs.

    HC-067047 hydrochloride purchased from MCE. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388.  [Abstract]

    HC067047 (10 mg/kg, tail vein injection, every 48 h for 3 weeks) decreased lesion size in the aorta of ApoE-/- mice.

    查看 TRP Channel 亚型特异性产品:

    查看所有亚型
    TRPA1 TRPC3 TRPC4 TRPC5 TRPM8 TRPM2 TRPM3 TRPM4 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    HC-067047 hydrochloride is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively[1].

    体外研究
    (In Vitro)

    HC-067047 hydrochloride（1 μM；24 小时；HEI-OC1 细胞）处理显着降低高糖培养的 HEI-OC1 细胞中的 mRNA 表达[2]。
    HC-067047 hydrochloride（1 μM；24 小时；HEI-OC1 细胞）处理显着降低 TRPV4 蛋白的表达[2]。
    HC-067047 hydrochloride（1 μM；48 小时；HEI-OC1 细胞）处理可抑制细胞增殖[2]。
    HC-067047 hydrochloride（1 μM；48 小时；HEI-OC1 细胞）处理可促进细胞凋亡[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    HC-067047 hydrochloride 相关抗体:
    体内研究
    (In Vivo)

    HC-067047 hydrochloride (0-50 mg/kg；腹腔注射；持续 30 分钟；环磷酰胺治疗的 WT 和 Trpv4-/- 小鼠，以及幼稚 WT 小鼠) 治疗可增加功能性膀胱容量并降低排尿频率 在患有膀胱炎的WT小鼠中。HC-067047 hydrochloride 不影响 Trpv4-/- 小鼠的膀胱功能[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    507.98

    Formula

    C26H29ClF3N3O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    HC-067047 hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    HC-0670471481646-76-7HC067047HC 067047TRP ChannelTransient receptor potential channelsHEI-OC1 cellTrpv4 KO miceInhibitorinhibitorinhibit

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