2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC2-IN-3

HDAC2-IN-3 是一种选择性的、口服有效的、可穿过血脑屏障的 HDAC2 抑制剂，其 IC50 为 14 nM。HDAC2-IN-3 可在细胞及体内上调组蛋白乙酰化水平，增强海马体长时程增强效应 (LTP)。HDAC2-IN-3 可用于阿尔茨海默病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

HDAC2-IN-3

HDAC2-IN-3 Chemical Structure

CAS No. : 2652579-44-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HDAC2-IN-3 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC2-IN-3 is a selective, orally active, blood-brain barrier permeable HDAC2 inhibitor with an IC50 of 14 nM. HDAC2-IN-3 upregulates histone acetylation levels in cells and in vivo, and enhances long-term potentiation (LTP) in the hippocampus. HDAC2-IN-3 can be used for the research of Alzheimer's disease[1].

IC50 & Target[1]

HDAC2

14 nM (IC50)

体外研究
(In Vitro)

HDAC2-IN-3 (Compound 11) (0.01-25.3 μM; 24 h) 可提高 C57B6J 小鼠胚胎原代皮质神经元中 H4K12 的乙酰化水平，最大作用效果达 71%，其 IC20 为 0.259 μM[1]。
HDAC2-IN-3 (0.0411-83.3 μM; 过夜) 在 HDAC2-KO K562 细胞中对 HDAC1 的活性较低，与阳性对照相比，H3K9 乙酰化水平最高仅升高 12%[1]。
HDAC2-IN-3 (0.1-25 μM; 48 h) 对人骨髓 CD34+祖细胞未表现出显著细胞毒性，在浓度高达 25 μM 时，其 IC50 > 25 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC2-IN-3 相关抗体:
体内研究
(In Vivo)

HDAC2-IN-3 (Compound 11) (50 mg/kg；口服；单次给药) 可使 APP/PS1 小鼠海马区 H4K12 乙酰化水平升高至溶媒对照组的 ~220%，证实其在体内可抑制 HDAC2[1]。
HDAC2-IN-3 (50 mg/kg；口服；每日一次；连续 10 天) 可显著增强 6 至 7 月龄 APP/PS1 小鼠的海马体 LTP，提示其具有改善学习与记忆形成的潜力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APP/PS1 (male; transgenic model generated by crossing Tg2576 mice with heterozygous PSEN1I213T KI mice)[1]
Dosage: 50 mg/kg
Administration: p.o.; single dose
Result: Elevated hippocampal H4K12 acetylation levels to approximately 220% of vehicle-treated control levels.
Animal Model: APP/PS1 (6- to 7-month-old; transgenic model generated by crossing Tg2576 mice with heterozygous PSEN1I213T KI mice)[1]
Dosage: 50 mg/kg
Administration: p.o.; daily; 10 days
Result: Significantly enhanced hippocampal LTP compared to vehicle-treated mice, with a statistically significant difference observed in the field excitatory postsynaptic potential slope following theta burst stimulation.
分子量

376.43

Formula

C19H16N6OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC2-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC2-IN-32652579-44-5HDACHistone deacetylasesHDAC2histone acetylationhuman blood cellsprimary cortical neuronshuman HDAC2Alzheimer's diseasehippocampal long-term potentiationC57B6J mouse embryosHDAC2-KO K562 cellsAPP/PS1 miceInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HDAC2-IN-3
目录号：
HY-182321
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z