2. Cell Cycle/DNA Damage Epigenetics Autophagy Apoptosis
  3. HDAC Autophagy Apoptosis
  4. HDAC6-IN-76

HDAC6-IN-76 (Compound G25) 是一种选择性 HDAC6 抑制剂，IC50 为 12 nM。HDAC6-IN-76 以 p53 依赖的方式诱导自噬 (Autophagy) 。HDAC6-IN-76 以 p53 依赖的方式诱导细胞凋亡 (Apoptosis)。HDAC6-IN-76 对血液系统恶性肿瘤，包括急性髓系白血病具有抗癌活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

HDAC6-IN-76

HDAC6-IN-76 Chemical Structure

CAS No. : 3110559-06-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HDAC6-IN-76 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-76 (Compound G25) is a selective HDAC6 inhibitor with an IC50 of 12 nM. HDAC6-IN-76 induces Autophagy in a p53-dependent manner. HDAC6-IN-76 induces Apoptosis in a p53-dependent manner. HDAC6-IN-76 exhibits anticancer activity against hematologic malignancies, including acute myeloid leukemia[1].

IC50 & Target[1]

HDAC6

12 nM (IC50)

体外研究
(In Vitro)

HDAC6-IN-76 是一种强效且选择性的 HDAC6 抑制剂，IC50 为 12 nM[1]。
HDAC6-IN-76 对白血病和实体瘤细胞系均表现出广谱、强效的抗增殖活性，对 MV4-11 细胞的活性尤为突出，IC50 为 0.028 μM[1]。
HDAC6-IN-76 (0.1-1 μM; 24 h) 可以剂量依赖的方式有效抑制 HCT116 结肠癌细胞的迁移[1]。
HDAC6-IN-76 (0.1-1 μM; 24 h) 可在 MV4-11 和 HL60 白血病细胞中以浓度依赖的方式诱导自噬[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-76 相关抗体:

Western Blot Analysis[1]

Cell Line: MV4-11 and HL60 leukemia cells
Concentration: 0.1-1 μM
Incubation Time: 24 h
Result: Led to a concentration-dependent increase in LC3B-II expression (conversion of LC3B-I to LC3B-II) in both MV4-11 and HL60 cells.
Caused a concentration-dependent decrease in p62 expression in both MV4-11 and HL60 cells, indicating enhanced autophagic flux.

Cell Cycle Analysis[1]

Cell Line: MV4-11 (p53-wild type) and HL60 (p53-null) leukemia cells
Concentration: 1 μM
Incubation Time: 24 h
Result: Arrested MV4-11 cells in the G0/G1 phase, with 86.71% of cells in this phase.
Arrested HL60 cells in the G2/M phase, with 34.13% of cells in this phase.
药代动力学
(Parmacokinetics)
Species Dose Route T1/2 Tmax Cmax AUC0-t AUC0-∞ MRT0-t MRT0-∞ Bioavailability C0
Rat[1] 2 mg/kg i.v. 0.208 h 0.0833 h 123 ng/mL 39.3 ng·h/mL 40.8 ng·h/mL 0.178 h 0.220 h / 213 ng/mL
Rat[1] 10 mg/kg i.p. 0.305 h 0.25 h 221 ng/mL 135 ng·h/mL 137 ng·h/mL 0.540 h 0.566 h 67.3 % /
体内研究
(In Vivo)

HDAC6-IN-76 (20 mg/kg；腹腔注射，每日 1 次) 在 MOLM-13-Luc 急性髓系白血病异种移植小鼠模型中表现出抗白血病活性，可通过肿瘤进展受抑制及生存期呈延长趋势得到证实[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

460.52

Formula

C24H32N2O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-76 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-763110559-06-0HDACAutophagyApoptosisHistone deacetylasesliver cancerautophagycolon cancerp53hematologic malignanciesHDAC6apoptosislung cancerα-tubulinacute myeloid leukemiaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HDAC6-IN-76
目录号：
HY-181805
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z