2. Neuronal Signaling
  3. Huntingtin
  4. Hepta-histidine

Hepta-histidine 是 Ku70-亨廷顿蛋白相互作用的抑制剂。Hepta-histidine 可以逆转由人诱导多能干细胞分化而来的原代神经元的形态异常。Hepta-histidine 可以延长重度亨廷顿病 R6/2 小鼠模型的寿命。Hepta-histidine 可在体外减轻 DNA 损伤。Hepta-histidine 可用于研究针对 Tau 蛋白相关神经退行性疾病 (例如阿尔茨海默病和亨廷顿病) 的抗聚集剂。

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Custom Peptide Synthesis

Hepta-histidine

Hepta-histidine Chemical Structure

CAS No. : 64134-31-2

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Hepta-histidine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hepta-histidine is an inhibitor of Ku70-Huntingtin protein interaction. Hepta-histidine can reverse the morphological abnormalities of primary neurons differentiatied from hiPSCs. Hepta-histidine prolongs the lifespan in severe Huntington’s disease R6/2 mouse model. Hepta-histidine ameliorates DNA damage in vitro. Hepta-histidine can be used to study anti-aggregation agent against Tau-associated neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease[1][2].

分子量

978.01

Formula

C42H51N21O8
CAS 号
Sequence

His-His-His-His-His-His-His
Sequence Shortening

HHHHHHH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hepta-histidine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hepta-histidine64134-31-2HuntingtinInhibitorinhibitorinhibit

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