1. Apoptosis
  2. Apoptosis
  3. Hesperetin triacetate

Hesperetin triacetate 是一种具有抗炎和抗肿瘤的活性化合物。Hesperetin triacetate 可在体外抑制牛血清白蛋白变性。Hesperetin triacetate 可在体内抑制角叉菜胶诱导的小鼠足肿胀。Hesperetin triacetate 对乳腺癌细胞具有抗增殖活性。Hesperetin triacetate 可诱导乳腺癌细胞的 DNA 降解和凋亡 (apoptosis)。Hesperetin triacetate 可用于乳腺癌和炎症相关研究。

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Hesperetin triacetate

Hesperetin triacetate Chemical Structure

CAS No. : 73489-97-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hesperetin triacetate is an active compound with anti-inflammatory and anti-tumor activities. Hesperetin triacetate inhibits bovine serum albumin denaturation in vitro. Hesperetin triacetate inhibits carrageenan-induced paw swelling in mice in vivo. Hesperetin triacetate exhibits anti-proliferative activity against breast cancer cells. Hesperetin triacetate induces DNA degradation and apoptosis in breast cancer cells. Hesperetin triacetate can be used in studies related to breast cancer and inflammation[1].

体外研究
(In Vitro)

Hesperetin triacetate (compound 4b) (48 h) 可强效抑制人乳腺癌 MCF-7 细胞的增殖L[1]
Hesperetin triacetate (36-48 h) 可诱导人乳腺癌 MCF-7 细胞发生凋亡性 DNA 片段化[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF-7 human breast cancer cells
Concentration: Concentrations to determine IC50
Incubation Time: 48 h
Result: Exhibited anti-proliferative activity against MCF-7 cells with an IC50 of 0.020 ± 0.001 μmol/mL.
体内研究
(In Vivo)

Hesperetin triacetate (compound 4b) (5% 乳膏制剂;局部给药;每日 2 次;连续 6 天) 在角叉菜胶诱导的小鼠足肿胀模型中表现出强效抗炎活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice treated carrageenan (22 ± 2 g)[1]
Dosage: 5% cream formulation
Administration: topical; twice daily; 6 days
Result: Reduced paw edema to 68.25 ± 5.68% at 3 hours post-carrageenan injection.
Reduced paw edema to 54.2 ± 10.5% at 1 day post-carrageenan injection.
Reduced paw edema to 46.34 ± 7.21% at 2 days post-carrageenan injection.
Reduced paw edema to 48.15 ± 5.36% at 3 days post-carrageenan injection.
Reduced paw edema to 36.41 ± 9.59% at 4 days post-carrageenan injection.
Reduced paw edema to 17.64 ± 6.35% at 5 days post-carrageenan injection.
Reduced paw edema to 19.67 ± 4.46% at 6 days post-carrageenan injection.
分子量

428.39

Formula

C22H20O9

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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