2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. HIF/HIF Prolyl-Hydroxylase Apoptosis HSP Caspase
  4. HIF-2α-IN-17

HIF-2α-IN-17 是一种选择性缺氧诱导因子 2α (HIF2α) 抑制剂，可与 HIF2α 的 PAS-B 结构域结合。HIF-2α-IN-17 可破坏 HIF2α 与分子伴侣 Hsp70 的相互作用，并诱导 HIF2α 的蛋白酶体降解。HIF-2α-IN-17 具有抗肿瘤的活性，可诱导癌细胞凋亡 (apoptosis)。HIF-2α-IN-17 可用于透明细胞肾癌等癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

HIF-2α-IN-17

HIF-2α-IN-17 Chemical Structure

CAS No. : 861212-49-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HIF-2α-IN-17 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

查看所有亚型
HIF-1α HIF

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HIF-2α-IN-17 is a selective hypoxia-inducible factor 2α (HIF2α) inhibitor that binds to the PAS-B domain of HIF2α. HIF-2α-IN-17 disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to proteasomal degradation of HIF2α. HIF-2α-IN-17 exhibits antitumor activity and induces apoptosis in cancer cells. HIF-2α-IN-17 is applicable for research on cancers such as clear cell renal cell carcinoma[1].

IC50 & Target[1]

HSP70

 

HIF-2α

 

Caspase-3

 

Caspase-7

 

体外研究
(In Vitro)

HIF-2α-IN-17 (Compound-c2) (0-30 μM；24 小时) 可选择性抑制 VHL 缺失的肾透明细胞癌 (ccRCC) 细胞系 (786-O、A498) 的活力，而对 VHL 阳性的 Caki-1 细胞或正常 HEK293 细胞无影响[1]。
HIF-2α-IN-17 (5-30 μM；24 小时) 通过激活 caspase-3 和 caspase-7 诱导 786-O 细胞发生细胞凋亡[1]。
HIF-2α-IN-17 (0-30 μM；8-24 小时) 可抑制 786-O 细胞中 HIF2α 的转录活性，并降低 HIF2α 靶基因 (VEGF、NDRG2、CCND1、GLUT1) 的表达水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HIF-2α-IN-17 相关抗体:

Western Blot Analysis[1]

Cell Line: 786-O
Concentration: 0, 5, 10, 20 and 30 μM
Incubation Time: 24 h
Result: Increased levels of cleaved caspase-3 and cleaved caspase-7 in a concentration-dependent manner.

Real Time qPCR[1]

Cell Line: 786-O
Concentration: 15 and 30 μM
Incubation Time: 24 h
Result: Downregulated mRNA expression of VEGF, NDRG2, CCND1, and GLUT1 in a concentration-dependent manner.
分子量

311.31

Formula

C17H14FN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HIF-2α-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIF-2α-IN-17861212-49-9HIF/HIF Prolyl-HydroxylaseApoptosisHSPCaspaseHypoxia-inducible factorsHIFsHIF-PHHeat shock proteinsclear cell renal cell carcinomaA498PAS-B domain786-OCaki-1Hsp70HEK293Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HIF-2α-IN-17
目录号：
HY-W470101
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z